STAT3-induced WDR1 overexpression promotes breast cancer cell migration

Joo Hyun Lee, Ji Eun Kim, Baek Gil Kim, Hyun Ho Han, Suki Kang, Nam Hoon Cho

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5′ upstream sequence (− 1971 to − 1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.

Original languageEnglish
Pages (from-to)1753-1760
Number of pages8
JournalCellular Signalling
Volume28
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Bibliographical note

Funding Information:
This study was supported by the Mid-Career Researcher Program through a National Research Foundation of Korea grant (No. 2016R1A2B4011115 ; CNH). There are no conflicts of interest associated with this work.

All Science Journal Classification (ASJC) codes

  • Cell Biology

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