STAT3-induced WDR1 overexpression promotes breast cancer cell migration

Joo Hyun Lee; Ji Eun Kim; Baek Gil Kim; Hyun Ho Han; Suki Kang; Nam Hoon Cho

doi:10.1016/j.cellsig.2016.08.006

STAT3-induced WDR1 overexpression promotes breast cancer cell migration

Joo Hyun Lee, Ji Eun Kim, Baek Gil Kim, Hyun Ho Han, Suki Kang, Nam Hoon Cho

Department of Pathology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5′ upstream sequence (− 1971 to − 1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.

Original language	English
Pages (from-to)	1753-1760
Number of pages	8
Journal	Cellular Signalling
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/j.cellsig.2016.08.006
Publication status	Published - 2016 Nov 1

Bibliographical note

Funding Information:
This study was supported by the Mid-Career Researcher Program through a National Research Foundation of Korea grant (No. 2016R1A2B4011115 ; CNH). There are no conflicts of interest associated with this work.

Publisher Copyright:
© 2016 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellsig.2016.08.006

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title = "STAT3-induced WDR1 overexpression promotes breast cancer cell migration",

abstract = "WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5′ upstream sequence (− 1971 to − 1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.",

author = "Lee, {Joo Hyun} and Kim, {Ji Eun} and Kim, {Baek Gil} and Han, {Hyun Ho} and Suki Kang and Cho, {Nam Hoon}",

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AU - Lee, Joo Hyun

AU - Kim, Ji Eun

AU - Kim, Baek Gil

AU - Han, Hyun Ho

AU - Kang, Suki

AU - Cho, Nam Hoon

N1 - Funding Information: This study was supported by the Mid-Career Researcher Program through a National Research Foundation of Korea grant (No. 2016R1A2B4011115 ; CNH). There are no conflicts of interest associated with this work. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/11/1

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AB - WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5′ upstream sequence (− 1971 to − 1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.

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STAT3-induced WDR1 overexpression promotes breast cancer cell migration

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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