Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry

Ryo Nakazato, Heidi Gransar, Daniel S. Berman, Victor Y. Cheng, Fay Y. Lin, Stephan Achenbach, Mouaz Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Hyuk Jae Chang, Ricardo C. Cury, Kavitha Chinnaiyan, Benjamin J.W. Chow, Augustin Delago, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Erica Maffei, Gilbert RaffLeslee J. Shaw, Todd C. Villines, Allison Dunning, Gudrun Feuchtner, Yong Jin Kim, Jonathon Leipsic, James K. Min

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Abstract

Objective: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. Methods: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. Results: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). Conclusion: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalAtherosclerosis
Volume225
Issue number1
DOIs
Publication statusPublished - 2012 Nov 1

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registries
Coronary Vessels
Odds Ratio
Confidence Intervals
Coronary Artery Disease
Coronary Angiography
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Nakazato, R., Gransar, H., Berman, D. S., Cheng, V. Y., Lin, F. Y., Achenbach, S., ... Min, J. K. (2012). Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry. Atherosclerosis, 225(1), 148-153. https://doi.org/10.1016/j.atherosclerosis.2012.08.002
Nakazato, Ryo ; Gransar, Heidi ; Berman, Daniel S. ; Cheng, Victor Y. ; Lin, Fay Y. ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Budoff, Matthew J. ; Cademartiri, Filippo ; Callister, Tracy Q. ; Chang, Hyuk Jae ; Cury, Ricardo C. ; Chinnaiyan, Kavitha ; Chow, Benjamin J.W. ; Delago, Augustin ; Hadamitzky, Martin ; Hausleiter, Joerg ; Kaufmann, Philipp ; Maffei, Erica ; Raff, Gilbert ; Shaw, Leslee J. ; Villines, Todd C. ; Dunning, Allison ; Feuchtner, Gudrun ; Kim, Yong Jin ; Leipsic, Jonathon ; Min, James K. / Statins use and coronary artery plaque composition : Results from the International Multicenter CONFIRM Registry. In: Atherosclerosis. 2012 ; Vol. 225, No. 1. pp. 148-153.
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title = "Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry",
abstract = "Objective: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. Methods: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. Results: The mean age was 59 ± 11 (55{\%} male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95{\%} confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95{\%} CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95{\%} CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95{\%} CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95{\%} CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95{\%} CI 0.94-1.25, p = 0.2). Conclusion: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.",
author = "Ryo Nakazato and Heidi Gransar and Berman, {Daniel S.} and Cheng, {Victor Y.} and Lin, {Fay Y.} and Stephan Achenbach and Mouaz Al-Mallah and Budoff, {Matthew J.} and Filippo Cademartiri and Callister, {Tracy Q.} and Chang, {Hyuk Jae} and Cury, {Ricardo C.} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Augustin Delago and Martin Hadamitzky and Joerg Hausleiter and Philipp Kaufmann and Erica Maffei and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Allison Dunning and Gudrun Feuchtner and Kim, {Yong Jin} and Jonathon Leipsic and Min, {James K.}",
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Nakazato, R, Gransar, H, Berman, DS, Cheng, VY, Lin, FY, Achenbach, S, Al-Mallah, M, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, HJ, Cury, RC, Chinnaiyan, K, Chow, BJW, Delago, A, Hadamitzky, M, Hausleiter, J, Kaufmann, P, Maffei, E, Raff, G, Shaw, LJ, Villines, TC, Dunning, A, Feuchtner, G, Kim, YJ, Leipsic, J & Min, JK 2012, 'Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry', Atherosclerosis, vol. 225, no. 1, pp. 148-153. https://doi.org/10.1016/j.atherosclerosis.2012.08.002

Statins use and coronary artery plaque composition : Results from the International Multicenter CONFIRM Registry. / Nakazato, Ryo; Gransar, Heidi; Berman, Daniel S.; Cheng, Victor Y.; Lin, Fay Y.; Achenbach, Stephan; Al-Mallah, Mouaz; Budoff, Matthew J.; Cademartiri, Filippo; Callister, Tracy Q.; Chang, Hyuk Jae; Cury, Ricardo C.; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; Delago, Augustin; Hadamitzky, Martin; Hausleiter, Joerg; Kaufmann, Philipp; Maffei, Erica; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd C.; Dunning, Allison; Feuchtner, Gudrun; Kim, Yong Jin; Leipsic, Jonathon; Min, James K.

In: Atherosclerosis, Vol. 225, No. 1, 01.11.2012, p. 148-153.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Statins use and coronary artery plaque composition

T2 - Results from the International Multicenter CONFIRM Registry

AU - Nakazato, Ryo

AU - Gransar, Heidi

AU - Berman, Daniel S.

AU - Cheng, Victor Y.

AU - Lin, Fay Y.

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Callister, Tracy Q.

AU - Chang, Hyuk Jae

AU - Cury, Ricardo C.

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Delago, Augustin

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Kaufmann, Philipp

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Dunning, Allison

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Leipsic, Jonathon

AU - Min, James K.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Objective: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. Methods: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. Results: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). Conclusion: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.

AB - Objective: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. Methods: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. Results: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). Conclusion: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation.

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DO - 10.1016/j.atherosclerosis.2012.08.002

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