Statistical implications of extrapolating the overall result to the target region in multi-regional clinical trials

Mathematics

• Treatment Effects 90%
• Clinical Trials 79%
• Target 71%
• Region of Interest 67%
• Extrapolate 47%
• Statistical method 32%
• Estimate 30%
• Estimator 19%
• Extrapolation 17%
• Hypothesis Testing 16%
• Relevance 16%
• Evidence 13%
• Range of data 10%

Business & Economics

• Clinical Trials 100%
• Treatment Effects 58%
• Regulatory Agencies 50%
• Regional Differences 22%
• Statistical Methods 20%
• Estimator 16%
• Extrapolation 12%
• Hypothesis Testing 10%
• Intrinsic 8%
• Guarantee 8%

Engineering & Materials Science

• Statistical methods 70%
• Extrapolation 45%
• Testing 21%