Stem cell impregnated carbon nanofibers/nanotubes for healing damaged neural tissue

Jong Eun Lee, Dongwoo Khang, Yong Eul Kim, Thomas Jay Webster

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

Carbon nanotubes and nanofibers are intriguing materials for medical applications due to their unique mechanical, electrical, and surface properties which have been shown to enhance in vitro neural cell functions compared to other central nervous system implant materials such as silicon. The objective of this in vivo study was to determine if stem cells can be combined with carbon nanofibers in the treatment of stroke damaged neural tissue in rats. Both hydrophobic and hydrophilic carbon nanofibers were mixed with stem cells and implanted into stroke damaged brains of rats for up to 3 weeks. Results | demonstrated the ability of stem cells to differentiate into neurons when injected with either, hydrophobic or hydrophilic carbon nanofibers into stroke damaged neural tissue. Hydrophobic nanofibers increased stem cell differentiation more than hydrophilic carbon nanofibers. Moreover, little scar tissue formation was observed surrounding both types of carbon nanofibers when implanted into the brain. Such results indicate promise for the use of carbon nanofibers as novel stem cell delivery vehicles for treating stroke damaged neural tissue.

Original languageEnglish
Title of host publicationNanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications
PublisherMaterials Research Society
Pages17-22
Number of pages6
ISBN (Print)9781558998711
DOIs
Publication statusPublished - 2006
Event2006 Materials Research Society Spring Meeting - San Francisco, CA, United States
Duration: 2006 Apr 182006 Apr 20

Publication series

NameMaterials Research Society Symposium Proceedings
Volume915
ISSN (Print)0272-9172

Other

Other2006 Materials Research Society Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period06/4/1806/4/20

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Lee, J. E., Khang, D., Kim, Y. E., & Webster, T. J. (2006). Stem cell impregnated carbon nanofibers/nanotubes for healing damaged neural tissue. In Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications (pp. 17-22). (Materials Research Society Symposium Proceedings; Vol. 915). Materials Research Society. https://doi.org/10.1557/proc-0915-r01-07