Step-down strategy in antiviral resistant chronic hepatitis B patients who achieved viral suppression with rescue combination therapy

Dong Yun Kim, Jun Yong Park

Research output: Contribution to journalReview articlepeer-review

Abstract

In the treatment of chronic hepatitis B (CHB) patients with drug resistance, rescue combination therapy leads to viral suppression in almost all patients. However, once it is achieved, lifelong maintenance especially, by using combination therapy is not always possible in a significant proportion of patients. At present, there is no consensus on whether it is possible to switch to monotherapy from combination therapy. However, there is robust evidence to support step-down therapy, which involves switching from combination therapy to monotherapy in antiviral resistant CHB patients who achieve complete viral response from combination therapy. We review the evidence in favor of switching to monotherapy in antiviral resistant CHB patients who achieve complete viral response by combination therapy.

Original languageEnglish
Pages (from-to)711-717
Number of pages7
JournalFuture Virology
Volume13
Issue number10
DOIs
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This work was supported by JW Pharmaceutical. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2018 2018 Future Medicine Ltd.

All Science Journal Classification (ASJC) codes

  • Virology

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