Abstract
In the treatment of chronic hepatitis B (CHB) patients with drug resistance, rescue combination therapy leads to viral suppression in almost all patients. However, once it is achieved, lifelong maintenance especially, by using combination therapy is not always possible in a significant proportion of patients. At present, there is no consensus on whether it is possible to switch to monotherapy from combination therapy. However, there is robust evidence to support step-down therapy, which involves switching from combination therapy to monotherapy in antiviral resistant CHB patients who achieve complete viral response from combination therapy. We review the evidence in favor of switching to monotherapy in antiviral resistant CHB patients who achieve complete viral response by combination therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 711-717 |
| Number of pages | 7 |
| Journal | Future Virology |
| Volume | 13 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Virology
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Step-down strategy in antiviral resistant chronic hepatitis B patients who achieved viral suppression with rescue combination therapy. / Kim, Dong Yun; Park, Junyong.
In: Future Virology, Vol. 13, No. 10, 01.01.2018, p. 711-717.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Step-down strategy in antiviral resistant chronic hepatitis B patients who achieved viral suppression with rescue combination therapy
AU - Kim, Dong Yun
AU - Park, Junyong
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In the treatment of chronic hepatitis B (CHB) patients with drug resistance, rescue combination therapy leads to viral suppression in almost all patients. However, once it is achieved, lifelong maintenance especially, by using combination therapy is not always possible in a significant proportion of patients. At present, there is no consensus on whether it is possible to switch to monotherapy from combination therapy. However, there is robust evidence to support step-down therapy, which involves switching from combination therapy to monotherapy in antiviral resistant CHB patients who achieve complete viral response from combination therapy. We review the evidence in favor of switching to monotherapy in antiviral resistant CHB patients who achieve complete viral response by combination therapy.
AB - In the treatment of chronic hepatitis B (CHB) patients with drug resistance, rescue combination therapy leads to viral suppression in almost all patients. However, once it is achieved, lifelong maintenance especially, by using combination therapy is not always possible in a significant proportion of patients. At present, there is no consensus on whether it is possible to switch to monotherapy from combination therapy. However, there is robust evidence to support step-down therapy, which involves switching from combination therapy to monotherapy in antiviral resistant CHB patients who achieve complete viral response from combination therapy. We review the evidence in favor of switching to monotherapy in antiviral resistant CHB patients who achieve complete viral response by combination therapy.
UR - http://www.scopus.com/inward/record.url?scp=85054703604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054703604&partnerID=8YFLogxK
U2 - 10.2217/fvl-2018-0078
DO - 10.2217/fvl-2018-0078
M3 - Review article
VL - 13
SP - 711
EP - 717
JO - Future Virology
JF - Future Virology
SN - 1746-0794
IS - 10
ER -