Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee, Yong Ho Shin, Yong Hyun Kim, Kee Young Lee, Chang Young Oh, Sung Jae Pyun, Hyun Ju Park, Jin-Hyun Jeong, Won Hun Ham

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalTetrahedron Asymmetry
Volume14
Issue number1
DOIs
Publication statusPublished - 2003 Jan 6

Fingerprint

Amination
Hydrogenation
Palladium
Biological Products
piperidine
synthesis
hydrogenation
palladium
methodology
products
spectaline

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Lee, Y. S., Shin, Y. H., Kim, Y. H., Lee, K. Y., Oh, C. Y., Pyun, S. J., ... Ham, W. H. (2003). Stereoselective synthesis of (+)-spectaline. Tetrahedron Asymmetry, 14(1), 87-93. https://doi.org/10.1016/S0957-4166(02)00794-2
Lee, Yiu Suk ; Shin, Yong Ho ; Kim, Yong Hyun ; Lee, Kee Young ; Oh, Chang Young ; Pyun, Sung Jae ; Park, Hyun Ju ; Jeong, Jin-Hyun ; Ham, Won Hun. / Stereoselective synthesis of (+)-spectaline. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 1. pp. 87-93.
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Lee, YS, Shin, YH, Kim, YH, Lee, KY, Oh, CY, Pyun, SJ, Park, HJ, Jeong, J-H & Ham, WH 2003, 'Stereoselective synthesis of (+)-spectaline', Tetrahedron Asymmetry, vol. 14, no. 1, pp. 87-93. https://doi.org/10.1016/S0957-4166(02)00794-2

Stereoselective synthesis of (+)-spectaline. / Lee, Yiu Suk; Shin, Yong Ho; Kim, Yong Hyun; Lee, Kee Young; Oh, Chang Young; Pyun, Sung Jae; Park, Hyun Ju; Jeong, Jin-Hyun; Ham, Won Hun.

In: Tetrahedron Asymmetry, Vol. 14, No. 1, 06.01.2003, p. 87-93.

Research output: Contribution to journalArticle

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AU - Park, Hyun Ju

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Lee YS, Shin YH, Kim YH, Lee KY, Oh CY, Pyun SJ et al. Stereoselective synthesis of (+)-spectaline. Tetrahedron Asymmetry. 2003 Jan 6;14(1):87-93. https://doi.org/10.1016/S0957-4166(02)00794-2