Stereoselective synthesis of (+)-spectaline

Yiu Suk Lee, Yong Ho Shin, Yong Hyun Kim, Kee Young Lee, Chang Young Oh, Sung Jae Pyun, Hyun Ju Park, Jin-Hyun Jeong, Won Hun Ham

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25 Citations (Scopus)

Abstract

Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalTetrahedron Asymmetry
Volume14
Issue number1
DOIs
Publication statusPublished - 2003 Jan 6

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Lee, Y. S., Shin, Y. H., Kim, Y. H., Lee, K. Y., Oh, C. Y., Pyun, S. J., Park, H. J., Jeong, J-H., & Ham, W. H. (2003). Stereoselective synthesis of (+)-spectaline. Tetrahedron Asymmetry, 14(1), 87-93. https://doi.org/10.1016/S0957-4166(02)00794-2