Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome

Ki Young Jung, Sung Min Kim, Jin Young Song, Byeong Uk Lee, Chany Lee, Sang Kun Lee, Yong Seo Koo, Yong Won Cho, Jeong Woo Choi, Kyung Hwan Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study. Methods: Thirteen drug-naïve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude. Results: After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score. Conclusion: Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.

Original languageEnglish
Pages (from-to)703-708
Number of pages6
JournalSleep Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Restless Legs Syndrome
Short-Term Memory
Sleep
Therapeutics
Evoked Potentials
Reaction Time
Depression
pramipexole
Sleep Initiation and Maintenance Disorders
Task Performance and Analysis
Pharmaceutical Preparations
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jung, Ki Young ; Kim, Sung Min ; Song, Jin Young ; Lee, Byeong Uk ; Lee, Chany ; Lee, Sang Kun ; Koo, Yong Seo ; Cho, Yong Won ; Choi, Jeong Woo ; Kim, Kyung Hwan. / Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome. In: Sleep Medicine. 2015 ; Vol. 16, No. 6. pp. 703-708.
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abstract = "Objectives: We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-na{\"i}ve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study. Methods: Thirteen drug-na{\"i}ve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude. Results: After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score. Conclusion: Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.",
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Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome. / Jung, Ki Young; Kim, Sung Min; Song, Jin Young; Lee, Byeong Uk; Lee, Chany; Lee, Sang Kun; Koo, Yong Seo; Cho, Yong Won; Choi, Jeong Woo; Kim, Kyung Hwan.

In: Sleep Medicine, Vol. 16, No. 6, 01.06.2015, p. 703-708.

Research output: Contribution to journalArticle

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AU - Kim, Sung Min

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AU - Lee, Sang Kun

AU - Koo, Yong Seo

AU - Cho, Yong Won

AU - Choi, Jeong Woo

AU - Kim, Kyung Hwan

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N2 - Objectives: We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study. Methods: Thirteen drug-naïve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude. Results: After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score. Conclusion: Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.

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