Steroid hormone metabolism in women with pelvic organ prolapse

Sang Wook Bai, Byung Hwa Jung, Bong Chul Chung, Sang Un Kim, Jeong Yeon Kim, KoonHo Rha, Sei Kwang Kim, Ki Hyun Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6 ± 6.5 and 63.5 ± 3.9 years, and the body mass index was 23.96 ± 3.14 and 24.11 ± 2.73 kg/m 2 in patients and normal subjects, respectively. The number of patients were 4 at stage 1, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3β,16β,17β-triol (5-AT), 11β-hydroxy an and 17βestradiol were significantly increased in the POP group as compared with the control group (0.76 ± 0.67 vs. 0.06 ± 0.03 μmol/g creatinine, P = .002, 1.16 ± 0.83 vs. 0.65 ± 0.23 μmol/g creatinine, P = .04; and 15.08 ± 9.81 vs. 8.53 ± 6.19 μmol/g creatinine, P = .04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80 ± 6.21 vs. 5.22 ± 4.89 μmol/g creatinine, P = .04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R = .418; P = .027; R = .46, P = .016). Among the estrogen metabolites, 17 β-estradiol correlated with POP-Q stage, but not significantly so (R = .38, P = .05), and the 17β-estradiol/ estrone ratio weakly correlated with stage (R=.14, P = .49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume47
Issue number4
Publication statusPublished - 2002 May 11

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Pelvic Organ Prolapse
Steroids
Hormones
Creatinine
Tetrahydrocortisone
Prolapse
Control Groups
Estradiol
Estrone
Gas Chromatography-Mass Spectrometry
Androgens
Volunteers
Estrogens
Body Mass Index
Age Groups

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Bai, S. W., Jung, B. H., Chung, B. C., Kim, S. U., Kim, J. Y., Rha, K., ... Park, K. H. (2002). Steroid hormone metabolism in women with pelvic organ prolapse. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 47(4), 303-308.
Bai, Sang Wook ; Jung, Byung Hwa ; Chung, Bong Chul ; Kim, Sang Un ; Kim, Jeong Yeon ; Rha, KoonHo ; Kim, Sei Kwang ; Park, Ki Hyun. / Steroid hormone metabolism in women with pelvic organ prolapse. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2002 ; Vol. 47, No. 4. pp. 303-308.
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title = "Steroid hormone metabolism in women with pelvic organ prolapse",
abstract = "OBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6 ± 6.5 and 63.5 ± 3.9 years, and the body mass index was 23.96 ± 3.14 and 24.11 ± 2.73 kg/m 2 in patients and normal subjects, respectively. The number of patients were 4 at stage 1, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3β,16β,17β-triol (5-AT), 11β-hydroxy an and 17βestradiol were significantly increased in the POP group as compared with the control group (0.76 ± 0.67 vs. 0.06 ± 0.03 μmol/g creatinine, P = .002, 1.16 ± 0.83 vs. 0.65 ± 0.23 μmol/g creatinine, P = .04; and 15.08 ± 9.81 vs. 8.53 ± 6.19 μmol/g creatinine, P = .04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80 ± 6.21 vs. 5.22 ± 4.89 μmol/g creatinine, P = .04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R = .418; P = .027; R = .46, P = .016). Among the estrogen metabolites, 17 β-estradiol correlated with POP-Q stage, but not significantly so (R = .38, P = .05), and the 17β-estradiol/ estrone ratio weakly correlated with stage (R=.14, P = .49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP.",
author = "Bai, {Sang Wook} and Jung, {Byung Hwa} and Chung, {Bong Chul} and Kim, {Sang Un} and Kim, {Jeong Yeon} and KoonHo Rha and Kim, {Sei Kwang} and Park, {Ki Hyun}",
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Bai, SW, Jung, BH, Chung, BC, Kim, SU, Kim, JY, Rha, K, Kim, SK & Park, KH 2002, 'Steroid hormone metabolism in women with pelvic organ prolapse', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 47, no. 4, pp. 303-308.

Steroid hormone metabolism in women with pelvic organ prolapse. / Bai, Sang Wook; Jung, Byung Hwa; Chung, Bong Chul; Kim, Sang Un; Kim, Jeong Yeon; Rha, KoonHo; Kim, Sei Kwang; Park, Ki Hyun.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 47, No. 4, 11.05.2002, p. 303-308.

Research output: Contribution to journalArticle

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T1 - Steroid hormone metabolism in women with pelvic organ prolapse

AU - Bai, Sang Wook

AU - Jung, Byung Hwa

AU - Chung, Bong Chul

AU - Kim, Sang Un

AU - Kim, Jeong Yeon

AU - Rha, KoonHo

AU - Kim, Sei Kwang

AU - Park, Ki Hyun

PY - 2002/5/11

Y1 - 2002/5/11

N2 - OBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6 ± 6.5 and 63.5 ± 3.9 years, and the body mass index was 23.96 ± 3.14 and 24.11 ± 2.73 kg/m 2 in patients and normal subjects, respectively. The number of patients were 4 at stage 1, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3β,16β,17β-triol (5-AT), 11β-hydroxy an and 17βestradiol were significantly increased in the POP group as compared with the control group (0.76 ± 0.67 vs. 0.06 ± 0.03 μmol/g creatinine, P = .002, 1.16 ± 0.83 vs. 0.65 ± 0.23 μmol/g creatinine, P = .04; and 15.08 ± 9.81 vs. 8.53 ± 6.19 μmol/g creatinine, P = .04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80 ± 6.21 vs. 5.22 ± 4.89 μmol/g creatinine, P = .04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R = .418; P = .027; R = .46, P = .016). Among the estrogen metabolites, 17 β-estradiol correlated with POP-Q stage, but not significantly so (R = .38, P = .05), and the 17β-estradiol/ estrone ratio weakly correlated with stage (R=.14, P = .49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP.

AB - OBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6 ± 6.5 and 63.5 ± 3.9 years, and the body mass index was 23.96 ± 3.14 and 24.11 ± 2.73 kg/m 2 in patients and normal subjects, respectively. The number of patients were 4 at stage 1, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3β,16β,17β-triol (5-AT), 11β-hydroxy an and 17βestradiol were significantly increased in the POP group as compared with the control group (0.76 ± 0.67 vs. 0.06 ± 0.03 μmol/g creatinine, P = .002, 1.16 ± 0.83 vs. 0.65 ± 0.23 μmol/g creatinine, P = .04; and 15.08 ± 9.81 vs. 8.53 ± 6.19 μmol/g creatinine, P = .04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80 ± 6.21 vs. 5.22 ± 4.89 μmol/g creatinine, P = .04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R = .418; P = .027; R = .46, P = .016). Among the estrogen metabolites, 17 β-estradiol correlated with POP-Q stage, but not significantly so (R = .38, P = .05), and the 17β-estradiol/ estrone ratio weakly correlated with stage (R=.14, P = .49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP.

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