OBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6 ± 6.5 and 63.5 ± 3.9 years, and the body mass index was 23.96 ± 3.14 and 24.11 ± 2.73 kg/m 2 in patients and normal subjects, respectively. The number of patients were 4 at stage 1, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3β,16β,17β-triol (5-AT), 11β-hydroxy an and 17βestradiol were significantly increased in the POP group as compared with the control group (0.76 ± 0.67 vs. 0.06 ± 0.03 μmol/g creatinine, P = .002, 1.16 ± 0.83 vs. 0.65 ± 0.23 μmol/g creatinine, P = .04; and 15.08 ± 9.81 vs. 8.53 ± 6.19 μmol/g creatinine, P = .04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80 ± 6.21 vs. 5.22 ± 4.89 μmol/g creatinine, P = .04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R = .418; P = .027; R = .46, P = .016). Among the estrogen metabolites, 17 β-estradiol correlated with POP-Q stage, but not significantly so (R = .38, P = .05), and the 17β-estradiol/ estrone ratio weakly correlated with stage (R=.14, P = .49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP.
|Number of pages||6|
|Journal||Journal of Reproductive Medicine for the Obstetrician and Gynecologist|
|Publication status||Published - 2002 May 11|
All Science Journal Classification (ASJC) codes
- Reproductive Medicine
- Obstetrics and Gynaecology