Stilbenes contribute to the anticancer effects of rheum undulatum L. Through activation of apoptosis

Tuy An Trinh, Dahae Lee, Seonju Park, Seung Hyun Kim, Jae Gyu Park, Ji Hwan Kim, Ki Sung Kang

Research output: Contribution to journalArticle

Abstract

Rheum undulatum L. (R. undulatum) is a medicinal plant used for the treatment of inflammatory diseases in East Asian countries. Numerous stilbenes isolated from R. undulatum have been revealed to possess anticancer effects. The aim of the present study was to evaluate the effect of extracts and compounds isolated from R. undulatum on human gastric cancer cell viability and to elucidate their molecular mechanism of action on the apoptosis pathway. The results demonstrated that aloe-emodin and chrysophanol 1-O-β-D-glucopyranoside, isolated from the methanolic extract of dried rhizomes of R. undulatum, exhibited anti-proliferative effects on the human gastric carcinoma cell line AGS, with IC 50 values of 84.66±0.44 and 68.28±0.29 µM, respectively. The percentage of apoptotic cells increased significantly following treatment with each compound at a concentration of 100 µM, compared with that in the non-treated group in the image-based cytometry assay. Western blot analysis revealed that these compounds activated the caspase cascade and inhibited B-cell lymphoma-2, an anti-apoptotic protein.

Original languageEnglish
Pages (from-to)2953-2959
Number of pages7
JournalOncology Letters
Volume17
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

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Rheum
Stilbenes
Apoptosis
Image Cytometry
Apoptosis Regulatory Proteins
Rhizome
B-Cell Lymphoma
Medicinal Plants
Caspases
Stomach Neoplasms
Cell Survival
Stomach
Western Blotting
Carcinoma
Cell Line

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Trinh, Tuy An ; Lee, Dahae ; Park, Seonju ; Kim, Seung Hyun ; Park, Jae Gyu ; Kim, Ji Hwan ; Kang, Ki Sung. / Stilbenes contribute to the anticancer effects of rheum undulatum L. Through activation of apoptosis. In: Oncology Letters. 2019 ; Vol. 17, No. 3. pp. 2953-2959.
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Stilbenes contribute to the anticancer effects of rheum undulatum L. Through activation of apoptosis. / Trinh, Tuy An; Lee, Dahae; Park, Seonju; Kim, Seung Hyun; Park, Jae Gyu; Kim, Ji Hwan; Kang, Ki Sung.

In: Oncology Letters, Vol. 17, No. 3, 01.03.2019, p. 2953-2959.

Research output: Contribution to journalArticle

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AU - Park, Jae Gyu

AU - Kim, Ji Hwan

AU - Kang, Ki Sung

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