Stimulation of mammalian cells using micro-bead impact in micro-bioreactor

Tae Jin Kim, Su Jin Kim, Hyo Il Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have conducted a new method in cell stimulation by utilizing micro-beads. HeLa cells were cultured in PDMS (Polydimethylsiloxane) microfluidic device and were stimulated using micro-beads with a mean diameter of 2Pm and 11Pm. The rate of proliferation of cells was compared for devices which circulated the cell culture medium either with or without micro-beads for a specific time interval. Two types of devices have been used for cell stimulation: a straight channel for two dimensional stimulation and a multi-layered channel for three dimensional stimulation (Figure 1).

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1345-1347
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period07/10/707/10/11

Bibliographical note

Funding Information:
This work was supported by ICINB of Seoul D&BR program (Grant no. 10816) and National Core Research Center (NCRC) for Na nomedical Technology of the Korea Science & Engineering Foundation (Grant no. 1R 5-2004-024-01001-0).

Publisher Copyright:
© 2007 CBMS.

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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