Abstract
Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
| Original language | English |
|---|---|
| Article number | 13 |
| Journal | Journal of Biological Engineering |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 Mar 23 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Environmental Engineering
- Biomedical Engineering
- Molecular Biology
- Cell Biology
Cite this
}
Strategies for using nanoprobes to perceive and treat cancer activity : A review. / Kang, Byunghoon; Kukreja, Aastha; Song, Daesub; Huh, yongmin; Haam, Seungjoo.
In: Journal of Biological Engineering, Vol. 11, No. 1, 13, 23.03.2017.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Strategies for using nanoprobes to perceive and treat cancer activity
T2 - A review
AU - Kang, Byunghoon
AU - Kukreja, Aastha
AU - Song, Daesub
AU - Huh, yongmin
AU - Haam, Seungjoo
PY - 2017/3/23
Y1 - 2017/3/23
N2 - Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
AB - Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
UR - http://www.scopus.com/inward/record.url?scp=85016148679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016148679&partnerID=8YFLogxK
U2 - 10.1186/s13036-016-0044-1
DO - 10.1186/s13036-016-0044-1
M3 - Review article
AN - SCOPUS:85016148679
VL - 11
JO - Journal of Biological Engineering
JF - Journal of Biological Engineering
SN - 1754-1611
IS - 1
M1 - 13
ER -