Strategies for using nanoprobes to perceive and treat cancer activity: A review

Byunghoon Kang; Aastha Kukreja; Daesub Song; Yong Min Huh; Seungjoo Haam

doi:10.1186/s13036-016-0044-1

Strategies for using nanoprobes to perceive and treat cancer activity: A review

Byunghoon Kang, Aastha Kukreja, Daesub Song, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.

Original language	English
Article number	13
Journal	Journal of Biological Engineering
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13036-016-0044-1
Publication status	Published - 2017 Mar 23

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

All Science Journal Classification (ASJC) codes

Environmental Engineering
Biomedical Engineering
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13036-016-0044-1

Cite this

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abstract = "Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.",

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AU - Kang, Byunghoon

AU - Kukreja, Aastha

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AU - Huh, Yong Min

AU - Haam, Seungjoo

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AB - Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.

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Strategies for using nanoprobes to perceive and treat cancer activity: A review

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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