Strategies for using nanoprobes to perceive and treat cancer activity: A review

Byunghoon Kang, Aastha Kukreja, Daesub Song, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.

Original languageEnglish
Article number13
JournalJournal of Biological Engineering
Volume11
Issue number1
DOIs
Publication statusPublished - 2017 Mar 23

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

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