Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro

In Kwon Choi, Hee Jae Shin, Hyi Seung Lee, Ho Jeong Kwon

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-α-induced NF-κB activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of NF-κB activation and can be a basis for the development of novel anti-angiogenic agents.

Original languageEnglish
Pages (from-to)1338-1343
Number of pages6
JournalJournal of microbiology and biotechnology
Volume17
Issue number8
Publication statusPublished - 2007 Aug 1

Fingerprint

Biological Products
Actinobacteria
Reporter Genes
Vascular Endothelial Growth Factor A
Neoplasms
Endothelial Cells
Neoplasm Metastasis
In Vitro Techniques
streptochlorin

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

@article{cc9ddf4fa8eb4caca34c7cac57e43c69,
title = "Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro",
abstract = "Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-α-induced NF-κB activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of NF-κB activation and can be a basis for the development of novel anti-angiogenic agents.",
author = "Choi, {In Kwon} and Shin, {Hee Jae} and Lee, {Hyi Seung} and Kwon, {Ho Jeong}",
year = "2007",
month = "8",
day = "1",
language = "English",
volume = "17",
pages = "1338--1343",
journal = "Journal of Microbiology and Biotechnology",
issn = "1017-7825",
publisher = "Korean Society for Microbiolog and Biotechnology",
number = "8",

}

Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro. / Choi, In Kwon; Shin, Hee Jae; Lee, Hyi Seung; Kwon, Ho Jeong.

In: Journal of microbiology and biotechnology, Vol. 17, No. 8, 01.08.2007, p. 1338-1343.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro

AU - Choi, In Kwon

AU - Shin, Hee Jae

AU - Lee, Hyi Seung

AU - Kwon, Ho Jeong

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-α-induced NF-κB activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of NF-κB activation and can be a basis for the development of novel anti-angiogenic agents.

AB - Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-α-induced NF-κB activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of NF-κB activation and can be a basis for the development of novel anti-angiogenic agents.

UR - http://www.scopus.com/inward/record.url?scp=38449087673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449087673&partnerID=8YFLogxK

M3 - Article

C2 - 18051603

AN - SCOPUS:38449087673

VL - 17

SP - 1338

EP - 1343

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

SN - 1017-7825

IS - 8

ER -