Streptochlorin, a marine natural product, inhibits NF-κB activation and suppresses angiogenesis in vitro

In Kwon Choi, Hee Jae Shin, Hyi Seung Lee, Ho Jeong Kwon

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Angiogenesis is an essential step in tumor progress and metastasis. Accordingly, small molecules that inhibit angiogenesis would appear to be a promising way to cure angiogenesis-related diseases, including cancer. In the present study, we report that streptochlorin, a small molecule from marine actinomycete, exhibits a potent antiangiogenic activity. The compound potently inhibited endothelial cell invasion and tube formation stimulated with vascular endothelial cell growth factor (VEGF) at low micromolar concentrations where it showed no cytotoxicity to the cells. In addition, streptochlorin inhibited TNF-α-induced NF-κB activation in the newly developed cell-based reporter gene assay. These data demonstrate that streptochlorin is a new inhibitor of NF-κB activation and can be a basis for the development of novel anti-angiogenic agents.

Original languageEnglish
Pages (from-to)1338-1343
Number of pages6
JournalJournal of microbiology and biotechnology
Volume17
Issue number8
Publication statusPublished - 2007 Aug

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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