Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.
Bibliographical noteFunding Information:
The authors express gratitude to S.-H.Yang and K.K. Kwon, Korea Ocean Research & Development Institute, for the identification of the microbial strain. Thanks are also extended to Y.H. Kim, Korea Basic Science Institute, Daejeon, Korea, for providing mass spectroscopic data. This research was supported in part by the Ministry of Maritime Affairs and Fisheries, Korea (MarineBio 21 program), Korea Ocean Research and Development Institute (Grant PE98230 to S.K.K. and PE98210 to H.S.P), the National R&D Program for Cancer Control, Ministry of Health and Welfare (0620360-1), and the Brain Korea 21 Project (to H.J.K.).
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Plant Science