Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973

Hee Jae Shin; Tae Sik Kim; Hyi Seung Lee; Jung Youl Park; In Kwon Choi; Ho Jeong Kwon

doi:10.1016/j.phytochem.2008.05.020

Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973

Hee Jae Shin, Tae Sik Kim, Hyi Seung Lee, Jung Youl Park, In Kwon Choi, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.

Original language	English
Pages (from-to)	2363-2366
Number of pages	4
Journal	Phytochemistry
Volume	69
Issue number	12
DOIs	https://doi.org/10.1016/j.phytochem.2008.05.020
Publication status	Published - 2008 Sept

Bibliographical note

Funding Information:
The authors express gratitude to S.-H.Yang and K.K. Kwon, Korea Ocean Research & Development Institute, for the identification of the microbial strain. Thanks are also extended to Y.H. Kim, Korea Basic Science Institute, Daejeon, Korea, for providing mass spectroscopic data. This research was supported in part by the Ministry of Maritime Affairs and Fisheries, Korea (MarineBio 21 program), Korea Ocean Research and Development Institute (Grant PE98230 to S.K.K. and PE98210 to H.S.P), the National R&D Program for Cancer Control, Ministry of Health and Welfare (0620360-1), and the Brain Korea 21 Project (to H.J.K.).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2008.05.020

Cite this

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title = "Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973",

abstract = "Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.",

author = "Shin, {Hee Jae} and Kim, {Tae Sik} and Lee, {Hyi Seung} and Park, {Jung Youl} and Choi, {In Kwon} and Kwon, {Ho Jeong}",

note = "Funding Information: The authors express gratitude to S.-H.Yang and K.K. Kwon, Korea Ocean Research & Development Institute, for the identification of the microbial strain. Thanks are also extended to Y.H. Kim, Korea Basic Science Institute, Daejeon, Korea, for providing mass spectroscopic data. This research was supported in part by the Ministry of Maritime Affairs and Fisheries, Korea (MarineBio 21 program), Korea Ocean Research and Development Institute (Grant PE98230 to S.K.K. and PE98210 to H.S.P), the National R&D Program for Cancer Control, Ministry of Health and Welfare (0620360-1), and the Brain Korea 21 Project (to H.J.K.).",

year = "2008",

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doi = "10.1016/j.phytochem.2008.05.020",

language = "English",

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journal = "Phytochemistry",

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AU - Shin, Hee Jae

AU - Kim, Tae Sik

AU - Lee, Hyi Seung

AU - Park, Jung Youl

AU - Choi, In Kwon

AU - Kwon, Ho Jeong

N1 - Funding Information: The authors express gratitude to S.-H.Yang and K.K. Kwon, Korea Ocean Research & Development Institute, for the identification of the microbial strain. Thanks are also extended to Y.H. Kim, Korea Basic Science Institute, Daejeon, Korea, for providing mass spectroscopic data. This research was supported in part by the Ministry of Maritime Affairs and Fisheries, Korea (MarineBio 21 program), Korea Ocean Research and Development Institute (Grant PE98230 to S.K.K. and PE98210 to H.S.P), the National R&D Program for Cancer Control, Ministry of Health and Welfare (0620360-1), and the Brain Korea 21 Project (to H.J.K.).

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AB - Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.

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Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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