Stress signaling pathways for the pathogenicity of Cryptococcus

Yong Sun Bahn, Kwang Woo Jung

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Sensing, responding, and adapting to the surrounding environment are crucial for all living organisms to survive, proliferate, and differentiate in their biological niches. This ability is also essential for Cryptococcus neoformans and its sibling species Cryptococcus gattii, as these pathogens have saprobic and parasitic life cycles in natural and animal host environments. The ability of Cryptococcus to cause fatal meningoencephalitis is highly related to its capability to remodel and optimize its metabolic and physiological status according to external cues. These cues act through multiple stress signaling pathways through a panoply of signaling components, including receptors/sensors, small GTPases, secondary messengers, kinases, transcription factors, and other miscellaneous adaptors or regulators. In this minireview, we summarize and highlight the importance of several stress signaling pathways that influence the pathogenicity of Cryptococcus and discuss future challenges in these areas.

Original languageEnglish
Pages (from-to)1564-1577
Number of pages14
JournalEukaryotic Cell
Volume12
Issue number12
DOIs
Publication statusPublished - 2013 Nov 29

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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