Stretchable ECM Patch Enhances Stem Cell Delivery for Post-MI Cardiovascular Repair

In Gul Kim, Mintai P. Hwang, Jin Sil Park, Su Hyun Kim, Jung Hyun Kim, Hyo Jin Kang, Ramesh Subbiah, Ung Hyun Ko, Jennifer H. Shin, Chong Hyun Kim, Donghoon Choi, Kwideok Park

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2 Citations (Scopus)

Abstract

Current cell-based therapies administered after myocardial infarction (MI) show limited efficacy due to subpar cell retention in a dynamically beating heart. In particular, cardiac patches generally provide a cursory level of cell attachment due to the lack of an adequate microenvironment. From this perspective, decellularized cell-derived ECM (CDM) is attractive in its recapitulation of a natural biophysical environment for cells. Unfortunately, its weak physical property renders it difficult to retain in its original form, limiting its full potential. Here, a novel strategy to peel CDM off from its underlying substrate is proposed. By physically stamping it onto a polyvinyl alcohol hydrogel, the resulting stretchable extracellular matrix (ECM) membrane preserves the natural microenvironment of CDM, thereby conferring a biological interface to a viscoelastic membrane. Its various mechanical and biological properties are characterized and its capacity to improve cardiomyocyte functionality is demonstrated. Finally, evidence of enhanced stem cell delivery using the stretchable ECM membrane is presented, which leads to improved cardiac remodeling in a rat MI model. A new class of material based on natural CDM is envisioned for the enhanced delivery of cells and growth factors that have a known affinity with ECM.

Original languageEnglish
Article number1900593
JournalAdvanced Healthcare Materials
Volume8
Issue number17
DOIs
Publication statusPublished - 2019 Sep 1

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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    Kim, I. G., Hwang, M. P., Park, J. S., Kim, S. H., Kim, J. H., Kang, H. J., Subbiah, R., Ko, U. H., Shin, J. H., Kim, C. H., Choi, D., & Park, K. (2019). Stretchable ECM Patch Enhances Stem Cell Delivery for Post-MI Cardiovascular Repair. Advanced Healthcare Materials, 8(17), [1900593]. https://doi.org/10.1002/adhm.201900593