Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease

Yoon Sang Oh, Joong Seok Kim, Eo Jin Hwang, Chul Hyoung Lyoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Olfactory dysfunction is a sensitive biomarker of neurodegeneration and a cardinal premotor symptom of Parkinson's disease (PD). Although several non-motor symptoms of PD have been correlated with decreased dopamine transporter uptake, olfactory dysfunction and reduced dopamine transporter uptake have not been widely investigated in PD. In this study, we aimed to identify the dopamine transporter status of the corpus striatum and thalamus using a magnetic resonance imaging (MRI)-guided spatial normalization method in patients with PD according to olfactory function. Methods: Among 87 PD patients, 50 had hyposmia and 37 had normosmia. All patients underwent positron emission tomography (PET) using 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (18F-FP-CIT) and T1-weighted MRI. PET images were normalized with simultaneously performed spatially normalized MRI and the regional standardized uptake value ratios (SUVR) with a volume of interest template were compared according to olfactory function. Results: The bilateral caudates and the left anterior and posterior putamen of the hyposmic group showed significantly reduced dopamine transporter uptake compared to the normosmic group. In partial correlation coefficient analysis, olfactory identification impairment was correlated with the SUVR values of the caudate nuclei. Conclusion: More dopaminergic impairment of the bilateral caudate nuclei was found in hyposmic PD. This finding suggests that decreased dopamine uptake in the caudate nucleus may be an imaging trace of olfactory dysfunction in patients with PD.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalParkinsonism and Related Disorders
Volume56
DOIs
Publication statusPublished - 2018 Nov

Fingerprint

Corpus Striatum
Parkinson Disease
Dopamine
Dopamine Plasma Membrane Transport Proteins
Caudate Nucleus
Magnetic Resonance Imaging
Positron-Emission Tomography
Nortropanes
Putamen
Thalamus
Carbon
Biomarkers

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

@article{4edd5b896dab4ae3b4a95427fb1bb793,
title = "Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease",
abstract = "Introduction: Olfactory dysfunction is a sensitive biomarker of neurodegeneration and a cardinal premotor symptom of Parkinson's disease (PD). Although several non-motor symptoms of PD have been correlated with decreased dopamine transporter uptake, olfactory dysfunction and reduced dopamine transporter uptake have not been widely investigated in PD. In this study, we aimed to identify the dopamine transporter status of the corpus striatum and thalamus using a magnetic resonance imaging (MRI)-guided spatial normalization method in patients with PD according to olfactory function. Methods: Among 87 PD patients, 50 had hyposmia and 37 had normosmia. All patients underwent positron emission tomography (PET) using 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (18F-FP-CIT) and T1-weighted MRI. PET images were normalized with simultaneously performed spatially normalized MRI and the regional standardized uptake value ratios (SUVR) with a volume of interest template were compared according to olfactory function. Results: The bilateral caudates and the left anterior and posterior putamen of the hyposmic group showed significantly reduced dopamine transporter uptake compared to the normosmic group. In partial correlation coefficient analysis, olfactory identification impairment was correlated with the SUVR values of the caudate nuclei. Conclusion: More dopaminergic impairment of the bilateral caudate nuclei was found in hyposmic PD. This finding suggests that decreased dopamine uptake in the caudate nucleus may be an imaging trace of olfactory dysfunction in patients with PD.",
author = "Oh, {Yoon Sang} and Kim, {Joong Seok} and Hwang, {Eo Jin} and Lyoo, {Chul Hyoung}",
year = "2018",
month = "11",
doi = "10.1016/j.parkreldis.2018.06.022",
language = "English",
volume = "56",
pages = "47--51",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",

}

Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease. / Oh, Yoon Sang; Kim, Joong Seok; Hwang, Eo Jin; Lyoo, Chul Hyoung.

In: Parkinsonism and Related Disorders, Vol. 56, 11.2018, p. 47-51.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Striatal dopamine uptake and olfactory dysfunction in patients with early Parkinson's disease

AU - Oh, Yoon Sang

AU - Kim, Joong Seok

AU - Hwang, Eo Jin

AU - Lyoo, Chul Hyoung

PY - 2018/11

Y1 - 2018/11

N2 - Introduction: Olfactory dysfunction is a sensitive biomarker of neurodegeneration and a cardinal premotor symptom of Parkinson's disease (PD). Although several non-motor symptoms of PD have been correlated with decreased dopamine transporter uptake, olfactory dysfunction and reduced dopamine transporter uptake have not been widely investigated in PD. In this study, we aimed to identify the dopamine transporter status of the corpus striatum and thalamus using a magnetic resonance imaging (MRI)-guided spatial normalization method in patients with PD according to olfactory function. Methods: Among 87 PD patients, 50 had hyposmia and 37 had normosmia. All patients underwent positron emission tomography (PET) using 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (18F-FP-CIT) and T1-weighted MRI. PET images were normalized with simultaneously performed spatially normalized MRI and the regional standardized uptake value ratios (SUVR) with a volume of interest template were compared according to olfactory function. Results: The bilateral caudates and the left anterior and posterior putamen of the hyposmic group showed significantly reduced dopamine transporter uptake compared to the normosmic group. In partial correlation coefficient analysis, olfactory identification impairment was correlated with the SUVR values of the caudate nuclei. Conclusion: More dopaminergic impairment of the bilateral caudate nuclei was found in hyposmic PD. This finding suggests that decreased dopamine uptake in the caudate nucleus may be an imaging trace of olfactory dysfunction in patients with PD.

AB - Introduction: Olfactory dysfunction is a sensitive biomarker of neurodegeneration and a cardinal premotor symptom of Parkinson's disease (PD). Although several non-motor symptoms of PD have been correlated with decreased dopamine transporter uptake, olfactory dysfunction and reduced dopamine transporter uptake have not been widely investigated in PD. In this study, we aimed to identify the dopamine transporter status of the corpus striatum and thalamus using a magnetic resonance imaging (MRI)-guided spatial normalization method in patients with PD according to olfactory function. Methods: Among 87 PD patients, 50 had hyposmia and 37 had normosmia. All patients underwent positron emission tomography (PET) using 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane (18F-FP-CIT) and T1-weighted MRI. PET images were normalized with simultaneously performed spatially normalized MRI and the regional standardized uptake value ratios (SUVR) with a volume of interest template were compared according to olfactory function. Results: The bilateral caudates and the left anterior and posterior putamen of the hyposmic group showed significantly reduced dopamine transporter uptake compared to the normosmic group. In partial correlation coefficient analysis, olfactory identification impairment was correlated with the SUVR values of the caudate nuclei. Conclusion: More dopaminergic impairment of the bilateral caudate nuclei was found in hyposmic PD. This finding suggests that decreased dopamine uptake in the caudate nucleus may be an imaging trace of olfactory dysfunction in patients with PD.

UR - http://www.scopus.com/inward/record.url?scp=85048586525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048586525&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2018.06.022

DO - 10.1016/j.parkreldis.2018.06.022

M3 - Article

C2 - 29925486

AN - SCOPUS:85048586525

VL - 56

SP - 47

EP - 51

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

ER -