Stroke: Molecular mechanisms and potential targets for treatment

Z. Zheng, J. E. Lee, M. A. Yenari

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Significant advances have been made over the past few years concerning the cellular and molecular events underlying ischemic cell death. The brain succumbs to ischemic injury as a result of loss of metabolic stores, excessive intracellular calcium accumulation, oxidative stress, and potentiation of the inflammatory response. Neurons can also die via necrotic or apoptotic mechanisms, depending on the nature and severity of the insult. While it has been widely held that ischemia is notable for cessation of protein synthesis, brain regions with marginal reduction in blood supply are especially capable of expressing a variety of genes, the functions of many of which are only beginning to be understood. Gene expression is also upregulated upon reperfusion and reoxygenation. As a result, a number of signaling pathways have been identified and are now known to contribute to ischemic progression or, in some cases, attempts at self preservation. This review will focus on the roles of stress genes, apoptosis-related genes, and inflammation. Knowledge of such molecular events has fueled interest in developing specific molecular targets with the hope of someday affecting outcome in clinical stroke.

Original languageEnglish
Pages (from-to)361-372
Number of pages12
JournalCurrent Molecular Medicine
Volume3
Issue number4
DOIs
Publication statusPublished - 2003 Jun 1

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Genes
Stroke
Brain
Oxidative stress
Cell death
Gene expression
Neurons
Reperfusion
Oxidative Stress
Blood
Cell Death
Ischemia
Apoptosis
Inflammation
Calcium
Gene Expression
Wounds and Injuries
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Zheng, Z. ; Lee, J. E. ; Yenari, M. A. / Stroke : Molecular mechanisms and potential targets for treatment. In: Current Molecular Medicine. 2003 ; Vol. 3, No. 4. pp. 361-372.
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Stroke : Molecular mechanisms and potential targets for treatment. / Zheng, Z.; Lee, J. E.; Yenari, M. A.

In: Current Molecular Medicine, Vol. 3, No. 4, 01.06.2003, p. 361-372.

Research output: Contribution to journalReview article

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AU - Lee, J. E.

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