Stromal CD10 expression and relationship to the E-cadherin/β-catenin complex in breast carcinoma

Hyunsoo Kim, Gou Young Kim, Youn Wha Kim, Yong Koo Park, Jeong Yoon Song, Sung Jig Lim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aims: Previous investigations have indicated that stromal CD10 expression, and altered levels of both E-cadherin and β-catenin, are associated with the biological aggressiveness of human carcinoma. The aim was to evaluate stromal CD10 expression and the association of stromal CD10 with E-cadherin and β-catenin in breast carcinoma. Methods and results: The expression of CD10, E-cadherin and β-catenin was immunohistochemically analysed in tissue microarrays containing 104 cases of invasive ductal carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Stromal CD10 was detected in 49.5% (50/101) of the IDC. No immunoreactivity was identified in the stromal cells of normal breast, DCIS or intraductal components of IDC. Accumulation of the cytoplasmic β-catenin was found in 87.0% (87/100) of the IDC. Stromal CD10 expression in IDC was significantly correlated with tumour size (P = 0.027), stage (P < 0.001) and histological grade (P = 0.006), the presence of nodal (P = 0.048) and distant (P = 0.015) metastases, oestrogen receptor-negative status (P = 0.016), cytoplasmic β-catenin accumulation (P = 0.031) and lower overall survival rate (P = 0.041). Conclusions: Stromal CD10 expression in IDC may constitute an important prognostic marker. Stromal CD10 expression with associated aggressive features might be related to aberrant β-catenin expression.

Original languageEnglish
Pages (from-to)708-719
Number of pages12
JournalHistopathology
Volume56
Issue number6
DOIs
Publication statusPublished - 2010 Jan 1

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Catenins
Ductal Carcinoma
Cadherins
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Stromal Cells
Estrogen Receptors
Neoplasm Metastasis
Carcinoma
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Kim, Hyunsoo ; Kim, Gou Young ; Kim, Youn Wha ; Park, Yong Koo ; Song, Jeong Yoon ; Lim, Sung Jig. / Stromal CD10 expression and relationship to the E-cadherin/β-catenin complex in breast carcinoma. In: Histopathology. 2010 ; Vol. 56, No. 6. pp. 708-719.
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abstract = "Aims: Previous investigations have indicated that stromal CD10 expression, and altered levels of both E-cadherin and β-catenin, are associated with the biological aggressiveness of human carcinoma. The aim was to evaluate stromal CD10 expression and the association of stromal CD10 with E-cadherin and β-catenin in breast carcinoma. Methods and results: The expression of CD10, E-cadherin and β-catenin was immunohistochemically analysed in tissue microarrays containing 104 cases of invasive ductal carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Stromal CD10 was detected in 49.5{\%} (50/101) of the IDC. No immunoreactivity was identified in the stromal cells of normal breast, DCIS or intraductal components of IDC. Accumulation of the cytoplasmic β-catenin was found in 87.0{\%} (87/100) of the IDC. Stromal CD10 expression in IDC was significantly correlated with tumour size (P = 0.027), stage (P < 0.001) and histological grade (P = 0.006), the presence of nodal (P = 0.048) and distant (P = 0.015) metastases, oestrogen receptor-negative status (P = 0.016), cytoplasmic β-catenin accumulation (P = 0.031) and lower overall survival rate (P = 0.041). Conclusions: Stromal CD10 expression in IDC may constitute an important prognostic marker. Stromal CD10 expression with associated aggressive features might be related to aberrant β-catenin expression.",
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Stromal CD10 expression and relationship to the E-cadherin/β-catenin complex in breast carcinoma. / Kim, Hyunsoo; Kim, Gou Young; Kim, Youn Wha; Park, Yong Koo; Song, Jeong Yoon; Lim, Sung Jig.

In: Histopathology, Vol. 56, No. 6, 01.01.2010, p. 708-719.

Research output: Contribution to journalArticle

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T1 - Stromal CD10 expression and relationship to the E-cadherin/β-catenin complex in breast carcinoma

AU - Kim, Hyunsoo

AU - Kim, Gou Young

AU - Kim, Youn Wha

AU - Park, Yong Koo

AU - Song, Jeong Yoon

AU - Lim, Sung Jig

PY - 2010/1/1

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N2 - Aims: Previous investigations have indicated that stromal CD10 expression, and altered levels of both E-cadherin and β-catenin, are associated with the biological aggressiveness of human carcinoma. The aim was to evaluate stromal CD10 expression and the association of stromal CD10 with E-cadherin and β-catenin in breast carcinoma. Methods and results: The expression of CD10, E-cadherin and β-catenin was immunohistochemically analysed in tissue microarrays containing 104 cases of invasive ductal carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Stromal CD10 was detected in 49.5% (50/101) of the IDC. No immunoreactivity was identified in the stromal cells of normal breast, DCIS or intraductal components of IDC. Accumulation of the cytoplasmic β-catenin was found in 87.0% (87/100) of the IDC. Stromal CD10 expression in IDC was significantly correlated with tumour size (P = 0.027), stage (P < 0.001) and histological grade (P = 0.006), the presence of nodal (P = 0.048) and distant (P = 0.015) metastases, oestrogen receptor-negative status (P = 0.016), cytoplasmic β-catenin accumulation (P = 0.031) and lower overall survival rate (P = 0.041). Conclusions: Stromal CD10 expression in IDC may constitute an important prognostic marker. Stromal CD10 expression with associated aggressive features might be related to aberrant β-catenin expression.

AB - Aims: Previous investigations have indicated that stromal CD10 expression, and altered levels of both E-cadherin and β-catenin, are associated with the biological aggressiveness of human carcinoma. The aim was to evaluate stromal CD10 expression and the association of stromal CD10 with E-cadherin and β-catenin in breast carcinoma. Methods and results: The expression of CD10, E-cadherin and β-catenin was immunohistochemically analysed in tissue microarrays containing 104 cases of invasive ductal carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Stromal CD10 was detected in 49.5% (50/101) of the IDC. No immunoreactivity was identified in the stromal cells of normal breast, DCIS or intraductal components of IDC. Accumulation of the cytoplasmic β-catenin was found in 87.0% (87/100) of the IDC. Stromal CD10 expression in IDC was significantly correlated with tumour size (P = 0.027), stage (P < 0.001) and histological grade (P = 0.006), the presence of nodal (P = 0.048) and distant (P = 0.015) metastases, oestrogen receptor-negative status (P = 0.016), cytoplasmic β-catenin accumulation (P = 0.031) and lower overall survival rate (P = 0.041). Conclusions: Stromal CD10 expression in IDC may constitute an important prognostic marker. Stromal CD10 expression with associated aggressive features might be related to aberrant β-catenin expression.

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