Structural and functional brain connectivity of people with obesity and prediction of body mass index using connectivity

Bo Yong Park, Jongbum Seo, Juneho Yi, Hyunjin Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Obesity is a medical condition affecting billions of people. Various neuroimaging methods including magnetic resonance imaging (MRI) have been used to obtain information about obesity. We adopted a multi-modal approach combining diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI) to incorporate complementary information and thus better investigate the brains of non-healthy weight subjects. The objective of this study was to explore multi-modal neuroimaging and use it to predict a practical clinical score, body mass index (BMI). Connectivity analysis was applied to DTI and rs-fMRI. Significant regions and associated imaging features were identified based on group-wise differences between healthy weight and non-healthy weight subjects. Six DTI-driven connections and 10 rs-fMRI-driven connectivities were identified. DTI-driven connections better reflected groupwise differences than did rs-fMRI-driven connectivity. We predicted BMI values using multimodal imaging features in a partial least-square regression framework (percent error 15.0%). Our study identified brain regions and imaging features that can adequately explain BMI. We identified potentially good imaging biomarker candidates for obesity-related diseases.

Original languageEnglish
Article numbere0141376
JournalPloS one
Volume10
Issue number11
DOIs
Publication statusPublished - 2015 Nov 4

Fingerprint

Diffusion tensor imaging
Diffusion Tensor Imaging
body mass index
Brain
Body Mass Index
obesity
Obesity
Magnetic Resonance Imaging
image analysis
brain
Imaging techniques
prediction
Neuroimaging
Weights and Measures
Multimodal Imaging
magnetic resonance imaging
Biomarkers
Magnetic resonance
Least-Squares Analysis
obesity-related diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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Structural and functional brain connectivity of people with obesity and prediction of body mass index using connectivity. / Park, Bo Yong; Seo, Jongbum; Yi, Juneho; Park, Hyunjin.

In: PloS one, Vol. 10, No. 11, e0141376, 04.11.2015.

Research output: Contribution to journalArticle

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