Structural connectivity networks in Alzheimer’s disease and Lewy body disease

Kyoungwon Baik, Jin Ju Yang, Jin Ho Jung, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Young H. Sohn, Phil Hyu Lee, Jong Min Lee, Byoung Seok Ye

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. Methods: We consecutively recruited 37 controls and 77 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI were supported by amyloid PET and dopamine transporter PET, respectively. There were 22 patients with ADCI, 19 patients with LBCI, and 36 patients with mixed ADCI/LBCI. We investigated the relationship between ADCI, LBCI, graph theory-based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. Results: LBCI, especially mixed with ADCI, was associated with increased normalized path length and decreased normalized global efficiency. LBCI was related to the decreased nodal degree of left caudate, which was further associated with broad cognitive dysfunction. Decreased left caudate nodal degree was associated with decreased fractional anisotropy (FA) in the brain regions vulnerable to LBD. Compared with the control group, the LBCI group had an increased betweenness centrality in the occipital nodes, which was associated with decreased FA in the WM adjacent to the striatum and visuospatial dysfunction. Conclusion: Concomitant ADCI and LBCI are associated with the accentuation of LBCI-related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI.

Original languageEnglish
Article numbere02112
JournalBrain and Behavior
Volume11
Issue number5
DOIs
Publication statusPublished - 2021 May

Bibliographical note

Funding Information:
Study funding: This work was supported by the National Research Foundation of Korea (NRF), grant funded by the Korea government (MSIT) (2019R1I1A1A01059529) and Severance Hospital Research fund for Clinical excellence (SHRC) (C‐2020‐0013). Jong‐Min Lee receives funding from 2019R1I1A1A01059529, and Byoung Seok Ye receives funding from C‐2020‐0013.

Publisher Copyright:
© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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