There still exists a need for developing more accurate generalized models for multiscale biofluids systems that enable clearer understanding of normal microcirculation and complexities of disease hemorheology. Such work will yield enhanced computational and experimental techniques for a wider class of flows having fluid-solid interactions, complex moving boundaries, and involving red blood cell (RBC) aggregation under physiological conditions. The work reported here has involved the multiphase non-Newtonian fluid simulations of pulsatile flow in an idealized coronary artery model have been performed using numerical and experimental studies. The secondary flow affected a local RBC accumulation on the inside curvature and it changed the local flow characteristics as well. RBC viscosity and wall shear stress (WSS) were changed with a function of local hemotocrit. In practical work involving specialized velocity measurement and acoustic emission monitoring of flow characteristics, flowinduced vibration effects, as well as material and physiological aspects of arterial systems were conducted. Computations of arterial flows were made and experimental investigations using glass microtube simulations of arteries were carried out. This work contributes to an understanding of the mechanics of relationship between the progression of certain inherited diseases and the mechanical deformation characteristics of the arterial system and the RBC.