Study of freshly excised brain tissues using terahertz imaging

Seung Jae Oh, Sang Hoon Kim, Young Bin Ji, Kiyoung Jeong, Yeonji Park, Jaemoon Yang, Dong Woo Park, Sam Kyu Noh, Seok Gu Kang, Yong Min Huh, Joo Hiuk Son, Jin Suck Suh

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

Original languageEnglish
Article numberA2837
Pages (from-to)2837-2842
Number of pages6
JournalBiomedical Optics Express
Volume5
Issue number8
DOIs
Publication statusPublished - 2014 Aug 1

Fingerprint

Terahertz Imaging
brain
tumors
Brain
Neoplasms
magnetic resonance
Magnetic Resonance Imaging
myelin
Hematoxylin
Eosine Yellowish-(YS)
Myelin Sheath
physicians
Brain Neoplasms
Paraffin
paraffins
surgery
Cell Count
margins
Physicians
Water

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Oh, S. J., Kim, S. H., Ji, Y. B., Jeong, K., Park, Y., Yang, J., ... Suh, J. S. (2014). Study of freshly excised brain tissues using terahertz imaging. Biomedical Optics Express, 5(8), 2837-2842. [A2837]. https://doi.org/10.1364/BOE.5.002837
Oh, Seung Jae ; Kim, Sang Hoon ; Ji, Young Bin ; Jeong, Kiyoung ; Park, Yeonji ; Yang, Jaemoon ; Park, Dong Woo ; Noh, Sam Kyu ; Kang, Seok Gu ; Huh, Yong Min ; Son, Joo Hiuk ; Suh, Jin Suck. / Study of freshly excised brain tissues using terahertz imaging. In: Biomedical Optics Express. 2014 ; Vol. 5, No. 8. pp. 2837-2842.
@article{7dc00f39a2254422b017de009773a67e,
title = "Study of freshly excised brain tissues using terahertz imaging",
abstract = "We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.",
author = "Oh, {Seung Jae} and Kim, {Sang Hoon} and Ji, {Young Bin} and Kiyoung Jeong and Yeonji Park and Jaemoon Yang and Park, {Dong Woo} and Noh, {Sam Kyu} and Kang, {Seok Gu} and Huh, {Yong Min} and Son, {Joo Hiuk} and Suh, {Jin Suck}",
year = "2014",
month = "8",
day = "1",
doi = "10.1364/BOE.5.002837",
language = "English",
volume = "5",
pages = "2837--2842",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "8",

}

Oh, SJ, Kim, SH, Ji, YB, Jeong, K, Park, Y, Yang, J, Park, DW, Noh, SK, Kang, SG, Huh, YM, Son, JH & Suh, JS 2014, 'Study of freshly excised brain tissues using terahertz imaging', Biomedical Optics Express, vol. 5, no. 8, A2837, pp. 2837-2842. https://doi.org/10.1364/BOE.5.002837

Study of freshly excised brain tissues using terahertz imaging. / Oh, Seung Jae; Kim, Sang Hoon; Ji, Young Bin; Jeong, Kiyoung; Park, Yeonji; Yang, Jaemoon; Park, Dong Woo; Noh, Sam Kyu; Kang, Seok Gu; Huh, Yong Min; Son, Joo Hiuk; Suh, Jin Suck.

In: Biomedical Optics Express, Vol. 5, No. 8, A2837, 01.08.2014, p. 2837-2842.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Study of freshly excised brain tissues using terahertz imaging

AU - Oh, Seung Jae

AU - Kim, Sang Hoon

AU - Ji, Young Bin

AU - Jeong, Kiyoung

AU - Park, Yeonji

AU - Yang, Jaemoon

AU - Park, Dong Woo

AU - Noh, Sam Kyu

AU - Kang, Seok Gu

AU - Huh, Yong Min

AU - Son, Joo Hiuk

AU - Suh, Jin Suck

PY - 2014/8/1

Y1 - 2014/8/1

N2 - We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

AB - We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

UR - http://www.scopus.com/inward/record.url?scp=84923172572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923172572&partnerID=8YFLogxK

U2 - 10.1364/BOE.5.002837

DO - 10.1364/BOE.5.002837

M3 - Article

AN - SCOPUS:84923172572

VL - 5

SP - 2837

EP - 2842

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 8

M1 - A2837

ER -

Oh SJ, Kim SH, Ji YB, Jeong K, Park Y, Yang J et al. Study of freshly excised brain tissues using terahertz imaging. Biomedical Optics Express. 2014 Aug 1;5(8):2837-2842. A2837. https://doi.org/10.1364/BOE.5.002837