Study of freshly excised brain tissues using terahertz imaging

Seung Jae Oh, Sang Hoon Kim, Young Bin Ji, Kiyoung Jeong, Yeonji Park, Jaemoon Yang, Dong Woo Park, Sam Kyu Noh, Seok Gu Kang, Yong Min Huh, Joo Hiuk Son, Jin Suck Suh

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Abstract

We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

Original languageEnglish
Article numberA2837
Pages (from-to)2837-2842
Number of pages6
JournalBiomedical Optics Express
Volume5
Issue number8
DOIs
Publication statusPublished - 2014 Aug 1

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Oh, S. J., Kim, S. H., Ji, Y. B., Jeong, K., Park, Y., Yang, J., Park, D. W., Noh, S. K., Kang, S. G., Huh, Y. M., Son, J. H., & Suh, J. S. (2014). Study of freshly excised brain tissues using terahertz imaging. Biomedical Optics Express, 5(8), 2837-2842. [A2837]. https://doi.org/10.1364/BOE.5.002837