Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats

Myung Sil Hwang, Mi Sun Park, Ji Young Moon, Ji Sun Lee, Young Na Yum, Eungkyung Yoon, Hyomin Lee, KiTaek Nam, Byung Mu Lee, Seung Hee Kim, Ki Hwa Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the highdose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverseeffect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d. Copyright

Original languageEnglish
Pages (from-to)2157-2165
Number of pages9
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume69
Issue number24
DOIs
Publication statusPublished - 2006 Jun 1

Fingerprint

Aristolochic Acids
Aristolochia
Sprague Dawley Rats
Toxicity
Rats
toxicity
Acids
acid
hematology
Biochemistry
biochemistry
food consumption
Hematology
Drinking
Aristolochiaceae
serum
Body Weight
mortality
Food
histopathology

All Science Journal Classification (ASJC) codes

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution

Cite this

Hwang, Myung Sil ; Park, Mi Sun ; Moon, Ji Young ; Lee, Ji Sun ; Yum, Young Na ; Yoon, Eungkyung ; Lee, Hyomin ; Nam, KiTaek ; Lee, Byung Mu ; Kim, Seung Hee ; Yang, Ki Hwa. / Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats. In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 2006 ; Vol. 69, No. 24. pp. 2157-2165.
@article{7ae6b3d8c3174a60acb60d34744dcf0c,
title = "Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats",
abstract = "The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the highdose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverseeffect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d. Copyright",
author = "Hwang, {Myung Sil} and Park, {Mi Sun} and Moon, {Ji Young} and Lee, {Ji Sun} and Yum, {Young Na} and Eungkyung Yoon and Hyomin Lee and KiTaek Nam and Lee, {Byung Mu} and Kim, {Seung Hee} and Yang, {Ki Hwa}",
year = "2006",
month = "6",
day = "1",
doi = "10.1080/15287390600747965",
language = "English",
volume = "69",
pages = "2157--2165",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "24",

}

Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats. / Hwang, Myung Sil; Park, Mi Sun; Moon, Ji Young; Lee, Ji Sun; Yum, Young Na; Yoon, Eungkyung; Lee, Hyomin; Nam, KiTaek; Lee, Byung Mu; Kim, Seung Hee; Yang, Ki Hwa.

In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 69, No. 24, 01.06.2006, p. 2157-2165.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats

AU - Hwang, Myung Sil

AU - Park, Mi Sun

AU - Moon, Ji Young

AU - Lee, Ji Sun

AU - Yum, Young Na

AU - Yoon, Eungkyung

AU - Lee, Hyomin

AU - Nam, KiTaek

AU - Lee, Byung Mu

AU - Kim, Seung Hee

AU - Yang, Ki Hwa

PY - 2006/6/1

Y1 - 2006/6/1

N2 - The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the highdose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverseeffect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d. Copyright

AB - The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the highdose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverseeffect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d. Copyright

UR - http://www.scopus.com/inward/record.url?scp=33750739226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750739226&partnerID=8YFLogxK

U2 - 10.1080/15287390600747965

DO - 10.1080/15287390600747965

M3 - Article

C2 - 17062506

AN - SCOPUS:33750739226

VL - 69

SP - 2157

EP - 2165

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 24

ER -