Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats

Myung Sil Hwang, Mi Sun Park, Ji Young Moon, Ji Sun Lee, Young Na Yum, Eungkyung Yoon, Hyomin Lee, Ki Taek Nam, Byung Mu Lee, Seung Hee Kim, Ki Hwa Yang

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Abstract

The subchronic toxicity of Aristolochiae fructus containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 d at dose levels of 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, hematology, serum biochemistry, organ weights, and histopathology were examined. Significant decreases in body weight gain were noted in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 d and did not recover in the highdose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, hematology, or serum biochemistry in the treatment groups versus control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥ 0.5 mg/kg/day AAs. For both genders, the no-observed-adverseeffect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg/kg/d. Copyright

Original languageEnglish
Pages (from-to)2157-2165
Number of pages9
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume69
Issue number24
DOIs
Publication statusPublished - 2006 Jun 1

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Hwang, M. S., Park, M. S., Moon, J. Y., Lee, J. S., Yum, Y. N., Yoon, E., Lee, H., Nam, K. T., Lee, B. M., Kim, S. H., & Yang, K. H. (2006). Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in sprague-dawley rats. Journal of Toxicology and Environmental Health - Part A: Current Issues, 69(24), 2157-2165. https://doi.org/10.1080/15287390600747965