Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD)

Seok Jong Chung; Jong Hun Kim; Jeong Hee Cho; Gyu Sik Kim; Sun Ah Choi; Phil Hyu Lee; Jun Hong Lee

doi:10.1016/j.archger.2013.10.006

Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD)

Seok Jong Chung, Jong Hun Kim, Jeong Hee Cho, Gyu Sik Kim, Sun Ah Choi, Phil Hyu Lee, Jun Hong Lee

Department of Neurology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.

Original language	English
Pages (from-to)	231-235
Number of pages	5
Journal	Archives of Gerontology and Geriatrics
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/j.archger.2013.10.006
Publication status	Published - 2014 Mar

Bibliographical note

Funding Information:
S.J. Chung, J.H. Cho, G.S. Kim, S.A. Choi, P.H. Lee, and J.H. Lee report no disclosures. J.H. Kim receives an intramural fund from Ilsan Hospital, National Health Insurance Corporation, a fund from Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea (A102065). There are no financial relationships among authors.

Funding Information:
This study was supported by Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea ( HI10C2020 ). This funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

All Science Journal Classification (ASJC) codes

Health(social science)
Ageing
Gerontology
Geriatrics and Gerontology

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@article{f039a3d255d0487fad1c365e5755cdeb,

title = "Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD)",

abstract = "Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.",

author = "Chung, {Seok Jong} and Kim, {Jong Hun} and Cho, {Jeong Hee} and Kim, {Gyu Sik} and Choi, {Sun Ah} and Lee, {Phil Hyu} and Lee, {Jun Hong}",

note = "Funding Information: S.J. Chung, J.H. Cho, G.S. Kim, S.A. Choi, P.H. Lee, and J.H. Lee report no disclosures. J.H. Kim receives an intramural fund from Ilsan Hospital, National Health Insurance Corporation, a fund from Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea (A102065). There are no financial relationships among authors. Funding Information: This study was supported by Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea ( HI10C2020 ). This funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. ",

year = "2014",

month = mar,

doi = "10.1016/j.archger.2013.10.006",

language = "English",

volume = "58",

pages = "231--235",

journal = "Archives of Gerontology and Geriatrics",

issn = "0167-4943",

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Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD). / Chung, Seok Jong; Kim, Jong Hun; Cho, Jeong Hee; Kim, Gyu Sik; Choi, Sun Ah; Lee, Phil Hyu; Lee, Jun Hong.

In: Archives of Gerontology and Geriatrics, Vol. 58, No. 2, 03.2014, p. 231-235.

Research output: Contribution to journal › Article › peer-review

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T1 - Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD)

AU - Chung, Seok Jong

AU - Kim, Jong Hun

AU - Cho, Jeong Hee

AU - Kim, Gyu Sik

AU - Choi, Sun Ah

AU - Lee, Phil Hyu

AU - Lee, Jun Hong

N1 - Funding Information: S.J. Chung, J.H. Cho, G.S. Kim, S.A. Choi, P.H. Lee, and J.H. Lee report no disclosures. J.H. Kim receives an intramural fund from Ilsan Hospital, National Health Insurance Corporation, a fund from Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea (A102065). There are no financial relationships among authors. Funding Information: This study was supported by Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea ( HI10C2020 ). This funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

PY - 2014/3

Y1 - 2014/3

N2 - Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.

AB - Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.

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