Abstract
Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.
| Original language | English |
|---|---|
| Pages (from-to) | 231-235 |
| Number of pages | 5 |
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 58 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Health(social science)
- Ageing
- Gerontology
- Geriatrics and Gerontology
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Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD). / Chung, Seok Jong; Kim, Jong Hun; Cho, Jeong Hee; Kim, Gyu Sik; Choi, Sun Ah; Lee, philhyu; Lee, Jun Hong.
In: Archives of Gerontology and Geriatrics, Vol. 58, No. 2, 01.03.2014, p. 231-235.Research output: Contribution to journal › Article
TY - JOUR
T1 - Subcortical vascular dementia (SVaD) without hypertension (HTN) may be a unique subtype of vascular dementia (VaD)
AU - Chung, Seok Jong
AU - Kim, Jong Hun
AU - Cho, Jeong Hee
AU - Kim, Gyu Sik
AU - Choi, Sun Ah
AU - Lee, philhyu
AU - Lee, Jun Hong
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.
AB - Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.
UR - http://www.scopus.com/inward/record.url?scp=84890859534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890859534&partnerID=8YFLogxK
U2 - 10.1016/j.archger.2013.10.006
DO - 10.1016/j.archger.2013.10.006
M3 - Article
C2 - 24238885
AN - SCOPUS:84890859534
VL - 58
SP - 231
EP - 235
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2
ER -