Although HTN is the most important factor in the pathogenesis of SVaD, about 20% of patients with SVaD do not have HTN. We hypothesize that SVaD without HTN may have strong risk factors other than HTN, and the study on this group can elucidate the risk factors for SVaD. We included 332 patients with SVaD from the database of the Clinical Research Center for Dementia of South Korea (CREDOS) study. Among them, 26.2% of patients (87 out of 332) had no history of HTN. We analyzed the differences in risk factors, clinical features, and survival time of SVaD according to HTN. Contrary to our expectations, SVaD without HTN had less known vascular risk factors such as diabetes mellitus (DM), dyslipidemia, and obesity. In addition, SVaD without HTN had different clinical features including less depression, focal neurological signs or symptoms and more features of disinhibition. However, although SVaD without HTN had less known vascular risk factors that can shorten survival times, the survival times did not differ according to the presence of HTN. SVaD without HTN may be a unique subtype of SVaD and can be a target group for studies of unknown risk factors for SVaD.
Bibliographical noteFunding Information:
S.J. Chung, J.H. Cho, G.S. Kim, S.A. Choi, P.H. Lee, and J.H. Lee report no disclosures. J.H. Kim receives an intramural fund from Ilsan Hospital, National Health Insurance Corporation, a fund from Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea (A102065). There are no financial relationships among authors.
This study was supported by Korean Society of Geriatric Neurology and a grant from the Korea Health 21 R&D Project, Ministry of Health, Welfare, and 178 Family Affairs, Republic of Korea ( HI10C2020 ). This funding source had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
All Science Journal Classification (ASJC) codes
- Health(social science)
- Geriatrics and Gerontology