Successful treatment of actinic keratosis with imiquimod cream 5%

A report of six cases

S. N. Chang, Y. L. Chung, S. C. Kim, J. Y. Sim, W. H. Park

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Background: Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil. Objectives: The aim of this study is to report six cases of AK treated with a potential new topical therapy, imiquimod. Methods: Subjects included in this study had suffered with recurrent AK for between 5 and 16 years. All six men were treated with imiquimod 5% cream three times a week for 6-8 weeks. In the event of a local skin reaction treatment was modified to two times per week. Results: All the AK lesions were successfully cleared after treatment with imiquimod cream 5% for 6-8 weeks. Histologically, no apparent signs of persisting AK could be detected, and no recurrences were reported during follow up. Conclusions: This study suggests that imiquimod may be useful as a new therapy for the treatment of actinic keratoses.

Original languageEnglish
Pages (from-to)1050-1053
Number of pages4
JournalBritish Journal of Dermatology
Volume144
Issue number5
DOIs
Publication statusPublished - 2001 Dec 1

Fingerprint

imiquimod
Actinic Keratosis
Therapeutics
Cryotherapy
Fluorouracil
Recurrence
Skin

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Chang, S. N. ; Chung, Y. L. ; Kim, S. C. ; Sim, J. Y. ; Park, W. H. / Successful treatment of actinic keratosis with imiquimod cream 5% : A report of six cases. In: British Journal of Dermatology. 2001 ; Vol. 144, No. 5. pp. 1050-1053.
@article{e6685c15997d4aa589a307e16f6ed8a3,
title = "Successful treatment of actinic keratosis with imiquimod cream 5{\%}: A report of six cases",
abstract = "Background: Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil. Objectives: The aim of this study is to report six cases of AK treated with a potential new topical therapy, imiquimod. Methods: Subjects included in this study had suffered with recurrent AK for between 5 and 16 years. All six men were treated with imiquimod 5{\%} cream three times a week for 6-8 weeks. In the event of a local skin reaction treatment was modified to two times per week. Results: All the AK lesions were successfully cleared after treatment with imiquimod cream 5{\%} for 6-8 weeks. Histologically, no apparent signs of persisting AK could be detected, and no recurrences were reported during follow up. Conclusions: This study suggests that imiquimod may be useful as a new therapy for the treatment of actinic keratoses.",
author = "Chang, {S. N.} and Chung, {Y. L.} and Kim, {S. C.} and Sim, {J. Y.} and Park, {W. H.}",
year = "2001",
month = "12",
day = "1",
doi = "10.1046/j.1365-2133.2001.04197.x",
language = "English",
volume = "144",
pages = "1050--1053",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "5",

}

Successful treatment of actinic keratosis with imiquimod cream 5% : A report of six cases. / Chang, S. N.; Chung, Y. L.; Kim, S. C.; Sim, J. Y.; Park, W. H.

In: British Journal of Dermatology, Vol. 144, No. 5, 01.12.2001, p. 1050-1053.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Successful treatment of actinic keratosis with imiquimod cream 5%

T2 - A report of six cases

AU - Chang, S. N.

AU - Chung, Y. L.

AU - Kim, S. C.

AU - Sim, J. Y.

AU - Park, W. H.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Background: Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil. Objectives: The aim of this study is to report six cases of AK treated with a potential new topical therapy, imiquimod. Methods: Subjects included in this study had suffered with recurrent AK for between 5 and 16 years. All six men were treated with imiquimod 5% cream three times a week for 6-8 weeks. In the event of a local skin reaction treatment was modified to two times per week. Results: All the AK lesions were successfully cleared after treatment with imiquimod cream 5% for 6-8 weeks. Histologically, no apparent signs of persisting AK could be detected, and no recurrences were reported during follow up. Conclusions: This study suggests that imiquimod may be useful as a new therapy for the treatment of actinic keratoses.

AB - Background: Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil. Objectives: The aim of this study is to report six cases of AK treated with a potential new topical therapy, imiquimod. Methods: Subjects included in this study had suffered with recurrent AK for between 5 and 16 years. All six men were treated with imiquimod 5% cream three times a week for 6-8 weeks. In the event of a local skin reaction treatment was modified to two times per week. Results: All the AK lesions were successfully cleared after treatment with imiquimod cream 5% for 6-8 weeks. Histologically, no apparent signs of persisting AK could be detected, and no recurrences were reported during follow up. Conclusions: This study suggests that imiquimod may be useful as a new therapy for the treatment of actinic keratoses.

UR - http://www.scopus.com/inward/record.url?scp=0035726535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035726535&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2001.04197.x

DO - 10.1046/j.1365-2133.2001.04197.x

M3 - Article

VL - 144

SP - 1050

EP - 1053

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 5

ER -