Successful treatment of actinic keratosis with imiquimod cream 5%: A report of six cases

S. N. Chang, Y. L. Chung, S. C. Kim, J. Y. Sim, W. H. Park

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124 Citations (Scopus)

Abstract

Background: Actinic keratoses (AK) are premalignant lesions, which are routinely treated by destructive procedures such as cryotherapy, electrodessication or topical 5-fluorouracil. Objectives: The aim of this study is to report six cases of AK treated with a potential new topical therapy, imiquimod. Methods: Subjects included in this study had suffered with recurrent AK for between 5 and 16 years. All six men were treated with imiquimod 5% cream three times a week for 6-8 weeks. In the event of a local skin reaction treatment was modified to two times per week. Results: All the AK lesions were successfully cleared after treatment with imiquimod cream 5% for 6-8 weeks. Histologically, no apparent signs of persisting AK could be detected, and no recurrences were reported during follow up. Conclusions: This study suggests that imiquimod may be useful as a new therapy for the treatment of actinic keratoses.

Original languageEnglish
Pages (from-to)1050-1053
Number of pages4
JournalBritish Journal of Dermatology
Volume144
Issue number5
DOIs
Publication statusPublished - 2001 Dec 1

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All Science Journal Classification (ASJC) codes

  • Dermatology

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