Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy

Ji Eun Kim, Se Jin Park, Ji Young Oh, Hyeon Joo Jeong, Ji Hong Kim, Jaeil Shin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome. The patient was treated with a systemic corticosteroid (initially prednisolone, 2 mg/kg and later deflazacort 1 mg/kg) and topical steroid drops for 1 month. Azathioprine was later added to the treatment regimen and the systemic steroid was slowly tapered. The final outcome of renal-ocular disease was favorable in the patient. However, long-term follow-up is necessary to properly manage frequent relapses and incomplete renal recovery. TINU should be considered as a differential diagnosis in children with uveitis or acute renal failure.

Original languageEnglish
Pages (from-to)S99-S102
JournalKorean Journal of Pediatrics
Volume59
DOIs
Publication statusPublished - 2016 Nov 1

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Azathioprine
Steroids
Kidney
Panuveitis
Eye Diseases
Uveitis
Rare Diseases
Prednisolone
Diagnostic Errors
Acute Kidney Injury
Renal Insufficiency
Adrenal Cortex Hormones
Differential Diagnosis
Therapeutics
Biopsy
Recurrence
Injections
Tubulointerstitial nephritis and uveitis

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Kim, Ji Eun ; Park, Se Jin ; Oh, Ji Young ; Jeong, Hyeon Joo ; Kim, Ji Hong ; Shin, Jaeil. / Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy. In: Korean Journal of Pediatrics. 2016 ; Vol. 59. pp. S99-S102.
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Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy. / Kim, Ji Eun; Park, Se Jin; Oh, Ji Young; Jeong, Hyeon Joo; Kim, Ji Hong; Shin, Jaeil.

In: Korean Journal of Pediatrics, Vol. 59, 01.11.2016, p. S99-S102.

Research output: Contribution to journalArticle

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