Abstract
Conclusions. These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway. Objective. Head and neck cancer is the sixth commonest cancer in the human body. Squamous cell carcinoma accounts for most sinonasal cancers. However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers. Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer. In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. Material and methods. Sinonasal cancer cells (Asan Medical Center-Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide. The degree of cell death was determined by means of a fluorescence-activated cell scan and the signal transduction pathway for cell death was examined. Results. Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner. Moreover, sulindac sulfide-induced apoptosis was abolished by treatment with the caspase inhibitor Z-VAD-fmk and the mitogen-activated protein kinase (MAPK) inhibitors PD98059 and SB203580.
| Original language | English |
|---|---|
| Pages (from-to) | 201-206 |
| Number of pages | 6 |
| Journal | Acta Oto-Laryngologica |
| Volume | 125 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Mar 10 |
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All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
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Sulindac sulfide-induced apoptosis in sinonasal cancer cells. / Kim, Chang Hoon; Song, Kyoung Seob; Kim, Kyung Su; Kim, Jin Young; Lee, Bong Jae; Lee, Jeung Gweon; Yoon, Joo Heon.
In: Acta Oto-Laryngologica, Vol. 125, No. 2, 10.03.2005, p. 201-206.Research output: Contribution to journal › Article
TY - JOUR
T1 - Sulindac sulfide-induced apoptosis in sinonasal cancer cells
AU - Kim, Chang Hoon
AU - Song, Kyoung Seob
AU - Kim, Kyung Su
AU - Kim, Jin Young
AU - Lee, Bong Jae
AU - Lee, Jeung Gweon
AU - Yoon, Joo Heon
PY - 2005/3/10
Y1 - 2005/3/10
N2 - Conclusions. These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway. Objective. Head and neck cancer is the sixth commonest cancer in the human body. Squamous cell carcinoma accounts for most sinonasal cancers. However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers. Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer. In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. Material and methods. Sinonasal cancer cells (Asan Medical Center-Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide. The degree of cell death was determined by means of a fluorescence-activated cell scan and the signal transduction pathway for cell death was examined. Results. Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner. Moreover, sulindac sulfide-induced apoptosis was abolished by treatment with the caspase inhibitor Z-VAD-fmk and the mitogen-activated protein kinase (MAPK) inhibitors PD98059 and SB203580.
AB - Conclusions. These results demonstrate that sulindac sulfide can induce cell death in maxillary cancer cells, and that sulindac sulfide-induced apoptosis is related to the extracellular signal-regulated kinase/p38 MAPK-caspase 3 signaling pathway. Objective. Head and neck cancer is the sixth commonest cancer in the human body. Squamous cell carcinoma accounts for most sinonasal cancers. However, little is known regarding the biochemical mechanism(s) of cell death in sinonasal cancers. Recently, human epidemiological and clinical intervention studies have indicated that sulindac, a non-steroidal anti-inflammatory drug, exhibits chemopreventive activity in colorectal cancer. In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. Material and methods. Sinonasal cancer cells (Asan Medical Center-Head and Neck Cancer 5) were treated with various concentrations of sulindac sulfide. The degree of cell death was determined by means of a fluorescence-activated cell scan and the signal transduction pathway for cell death was examined. Results. Human nasal cavity cancer cells treated with sulindac sulfide underwent cell death, and the induction of apoptosis occurred in a dose-dependent manner. Moreover, sulindac sulfide-induced apoptosis was abolished by treatment with the caspase inhibitor Z-VAD-fmk and the mitogen-activated protein kinase (MAPK) inhibitors PD98059 and SB203580.
UR - http://www.scopus.com/inward/record.url?scp=14344266116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14344266116&partnerID=8YFLogxK
U2 - 10.1080/00016480410020293
DO - 10.1080/00016480410020293
M3 - Article
C2 - 15880954
AN - SCOPUS:14344266116
VL - 125
SP - 201
EP - 206
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 2
ER -