SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2

Sun Mi Park, Myounghee Chae, Bo Kyoung Kim, Taegun Seo, Ik Soon Jang, Jong Soon Choi, Il Chul Kim, Je Ho Lee, Junsoo Park

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11 Citations (Scopus)


Interferon regulatory factor-1 (IRF-1) is an interferon-induced transcriptional activator that suppresses tumors by impeding cell proliferation. Recently, we demonstrated that the level of SUMOylated IRF-1 is elevated in tumor cells, and that SUMOylation of IRF-1 attenuates its tumor-suppressive function. Here we report that SUMOylated IRF-1 mimics IRF-2, an antagonistic repressor, and shows oncogenic potential. To demonstrate the role of SUMOylated IRF-1 in tumorigenesis, we used SUMO-IRF-1 recombinant protein. Stable expression of SUMO-IRF-1 in NIH3T3 cells resulted in focus formation and anchorage-independent growth in soft agar. Inoculation of SUMO-IRF-1-transfected cells into athymic nude mice resulted in tumor formation and infiltration of adipose tissues. Finally, we demonstrated that SUMO-IRF-1 transforms NIH3T3 cells in a dose-dependent manner suggesting that SUMOylated IRF-1 may act as an oncogenic protein in tumor cells.

Original languageEnglish
Pages (from-to)926-930
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Park, S. M., Chae, M., Kim, B. K., Seo, T., Jang, I. S., Choi, J. S., Kim, I. C., Lee, J. H., & Park, J. (2010). SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2. Biochemical and Biophysical Research Communications, 391(1), 926-930.