18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy

Hee Jin Kim, Hanna Cho, David J. Werring, Young Kyoung Jang, Yeo Jin Kim, Jin San Lee, Juyoun Lee, Soomin Jun, Seongbeom Park, Young Hoon Ryu, Jae Yong Choi, Young Seok Cho, Seung Hwan Moon, Duk L. Na, Chul Hyoung Lyoo, Sang Won Seo

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8 Citations (Scopus)

Abstract

Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11C-Pittsburgh Compound B (PiB) PET or 18F-florbetaben PET to evaluate amyloid burden, and 18F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalJournal of Alzheimer's Disease
Volume57
Issue number3
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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    Kim, H. J., Cho, H., Werring, D. J., Jang, Y. K., Kim, Y. J., Lee, J. S., Lee, J., Jun, S., Park, S., Ryu, Y. H., Choi, J. Y., Cho, Y. S., Moon, S. H., Na, D. L., Lyoo, C. H., & Seo, S. W. (2017). 18F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy. Journal of Alzheimer's Disease, 57(3), 711-716. https://doi.org/10.3233/JAD-161139