18 F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy

Hee Jin Kim, Hanna Cho, David J. Werring, Young Kyoung Jang, Yeo Jin Kim, Jin San Lee, Juyoun Lee, Soomin Jun, Seongbeom Park, Young Hoon Ryu, Jae Yong Choi, Young Seok Cho, Seung Hwan Moon, Duk L. Na, Chulhyoung Lyoo, Sang Won Seo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11 C-Pittsburgh Compound B (PiB) PET or 18 F-florbetaben PET to evaluate amyloid burden, and 18 F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18 F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalJournal of Alzheimer's Disease
Volume57
Issue number3
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Cerebral Amyloid Angiopathy
Siderosis
Amyloid
Blood Vessels
Cerebral Hemorrhage
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Kim, H. J., Cho, H., Werring, D. J., Jang, Y. K., Kim, Y. J., Lee, J. S., ... Seo, S. W. (2017). 18 F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy Journal of Alzheimer's Disease, 57(3), 711-716. https://doi.org/10.3233/JAD-161139
Kim, Hee Jin ; Cho, Hanna ; Werring, David J. ; Jang, Young Kyoung ; Kim, Yeo Jin ; Lee, Jin San ; Lee, Juyoun ; Jun, Soomin ; Park, Seongbeom ; Ryu, Young Hoon ; Choi, Jae Yong ; Cho, Young Seok ; Moon, Seung Hwan ; Na, Duk L. ; Lyoo, Chulhyoung ; Seo, Sang Won. / 18 F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy In: Journal of Alzheimer's Disease. 2017 ; Vol. 57, No. 3. pp. 711-716.
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abstract = "Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11 C-Pittsburgh Compound B (PiB) PET or 18 F-florbetaben PET to evaluate amyloid burden, and 18 F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18 F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.",
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Kim, HJ, Cho, H, Werring, DJ, Jang, YK, Kim, YJ, Lee, JS, Lee, J, Jun, S, Park, S, Ryu, YH, Choi, JY, Cho, YS, Moon, SH, Na, DL, Lyoo, C & Seo, SW 2017, '18 F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy ', Journal of Alzheimer's Disease, vol. 57, no. 3, pp. 711-716. https://doi.org/10.3233/JAD-161139

18 F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy . / Kim, Hee Jin; Cho, Hanna; Werring, David J.; Jang, Young Kyoung; Kim, Yeo Jin; Lee, Jin San; Lee, Juyoun; Jun, Soomin; Park, Seongbeom; Ryu, Young Hoon; Choi, Jae Yong; Cho, Young Seok; Moon, Seung Hwan; Na, Duk L.; Lyoo, Chulhyoung; Seo, Sang Won.

In: Journal of Alzheimer's Disease, Vol. 57, No. 3, 01.01.2017, p. 711-716.

Research output: Contribution to journalArticle

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AU - Kim, Hee Jin

AU - Cho, Hanna

AU - Werring, David J.

AU - Jang, Young Kyoung

AU - Kim, Yeo Jin

AU - Lee, Jin San

AU - Lee, Juyoun

AU - Jun, Soomin

AU - Park, Seongbeom

AU - Ryu, Young Hoon

AU - Choi, Jae Yong

AU - Cho, Young Seok

AU - Moon, Seung Hwan

AU - Na, Duk L.

AU - Lyoo, Chulhyoung

AU - Seo, Sang Won

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AB - Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11 C-Pittsburgh Compound B (PiB) PET or 18 F-florbetaben PET to evaluate amyloid burden, and 18 F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18 F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.

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