18 F-FDG PET-CT as a supplement to CT/MRI for detection of nodal metastasis in hypopharyngeal SCC with palpably negative neck

Ho Joon Lee, Jinna Kim, Ha Young Woo, Won Jun Kang, Jae Hoon Lee, Yoonwoo Koh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives/Hypothesis To determine the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal metastasis in patients with hypopharyngeal squamous cell carcinoma (SCC) with palpably negative neck and to assess the role of PET-CT as a supplement to CT/MR. Study Design Retrospective analysis. Methods A total of 39 patients with palpably negative neck (36 men and 3 women; average age 65.4 years) underwent tumor resection and neck dissection as primary treatment. All patients were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. Results Twenty (51.3%) of the 39 patients were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six patients who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. Conclusions The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal metastasis in patients with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection.

Original languageEnglish
Pages (from-to)1607-1612
Number of pages6
JournalLaryngoscope
Volume125
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

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Squamous Cell Carcinoma
Neck
Neoplasm Metastasis
Magnetic Resonance Spectroscopy
Neck Dissection
Magnetic Resonance Imaging
Positron Emission Tomography Computed Tomography
Palpation
Fluorodeoxyglucose F18
Retrospective Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Lee, Ho Joon ; Kim, Jinna ; Woo, Ha Young ; Kang, Won Jun ; Lee, Jae Hoon ; Koh, Yoonwoo. / 18 F-FDG PET-CT as a supplement to CT/MRI for detection of nodal metastasis in hypopharyngeal SCC with palpably negative neck In: Laryngoscope. 2015 ; Vol. 125, No. 7. pp. 1607-1612.
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title = "18 F-FDG PET-CT as a supplement to CT/MRI for detection of nodal metastasis in hypopharyngeal SCC with palpably negative neck",
abstract = "Objectives/Hypothesis To determine the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal metastasis in patients with hypopharyngeal squamous cell carcinoma (SCC) with palpably negative neck and to assess the role of PET-CT as a supplement to CT/MR. Study Design Retrospective analysis. Methods A total of 39 patients with palpably negative neck (36 men and 3 women; average age 65.4 years) underwent tumor resection and neck dissection as primary treatment. All patients were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. Results Twenty (51.3{\%}) of the 39 patients were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7{\%}, 57.1{\%}, and 65.7{\%}, respectively, but without statistical significance. Of the six patients who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. Conclusions The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal metastasis in patients with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection.",
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18 F-FDG PET-CT as a supplement to CT/MRI for detection of nodal metastasis in hypopharyngeal SCC with palpably negative neck . / Lee, Ho Joon; Kim, Jinna; Woo, Ha Young; Kang, Won Jun; Lee, Jae Hoon; Koh, Yoonwoo.

In: Laryngoscope, Vol. 125, No. 7, 01.07.2015, p. 1607-1612.

Research output: Contribution to journalArticle

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T1 - 18 F-FDG PET-CT as a supplement to CT/MRI for detection of nodal metastasis in hypopharyngeal SCC with palpably negative neck

AU - Lee, Ho Joon

AU - Kim, Jinna

AU - Woo, Ha Young

AU - Kang, Won Jun

AU - Lee, Jae Hoon

AU - Koh, Yoonwoo

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N2 - Objectives/Hypothesis To determine the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal metastasis in patients with hypopharyngeal squamous cell carcinoma (SCC) with palpably negative neck and to assess the role of PET-CT as a supplement to CT/MR. Study Design Retrospective analysis. Methods A total of 39 patients with palpably negative neck (36 men and 3 women; average age 65.4 years) underwent tumor resection and neck dissection as primary treatment. All patients were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. Results Twenty (51.3%) of the 39 patients were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six patients who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. Conclusions The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal metastasis in patients with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection.

AB - Objectives/Hypothesis To determine the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal metastasis in patients with hypopharyngeal squamous cell carcinoma (SCC) with palpably negative neck and to assess the role of PET-CT as a supplement to CT/MR. Study Design Retrospective analysis. Methods A total of 39 patients with palpably negative neck (36 men and 3 women; average age 65.4 years) underwent tumor resection and neck dissection as primary treatment. All patients were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. Results Twenty (51.3%) of the 39 patients were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six patients who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. Conclusions The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal metastasis in patients with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection.

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