Abstract
Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
| Original language | English |
|---|---|
| Article number | e71571 |
| Journal | PloS one |
| Volume | 8 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 Aug 5 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
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18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma : A Preliminary Study. / Ahn, Sung Jun; Park, Mi Suk; Kim, Kyung Ah; Park, Jun Yong; Kim, In Seong; Kang, Won Joon; Lee, Seung Koo; Kim, Myeong Jin.
In: PloS one, Vol. 8, No. 8, e71571, 05.08.2013.Research output: Contribution to journal › Article
TY - JOUR
T1 - 18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma
T2 - A Preliminary Study
AU - Ahn, Sung Jun
AU - Park, Mi Suk
AU - Kim, Kyung Ah
AU - Park, Jun Yong
AU - Kim, In Seong
AU - Kang, Won Joon
AU - Lee, Seung Koo
AU - Kim, Myeong Jin
PY - 2013/8/5
Y1 - 2013/8/5
N2 - Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
AB - Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.
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U2 - 10.1371/journal.pone.0071571
DO - 10.1371/journal.pone.0071571
M3 - Article
C2 - 23940769
AN - SCOPUS:84881115718
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 8
M1 - e71571
ER -