18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma: A Preliminary Study

Sung Jun Ahn, Mi Suk Park, Kyung Ah Kim, Jun Yong Park, In Seong Kim, Won Joon Kang, Seung Koo Lee, Myeong Jin Kim

Research output: Contribution to journalArticle

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Abstract

Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

Original languageEnglish
Article numbere71571
JournalPloS one
Volume8
Issue number8
DOIs
Publication statusPublished - 2013 Aug 5

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positron-emission tomography
Positron emission tomography
Diffusion Magnetic Resonance Imaging
hepatoma
Positron-Emission Tomography
Magnetic resonance imaging
Hepatocellular Carcinoma
Perfusion
diffusivity
image analysis
neoplasms
portal vein
thrombosis
Tumors
Portal Vein
Imaging techniques
Metabolism
metabolism
Neoplasms
Thrombosis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ahn, Sung Jun ; Park, Mi Suk ; Kim, Kyung Ah ; Park, Jun Yong ; Kim, In Seong ; Kang, Won Joon ; Lee, Seung Koo ; Kim, Myeong Jin. / 18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma : A Preliminary Study. In: PloS one. 2013 ; Vol. 8, No. 8.
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abstract = "Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.",
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18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma : A Preliminary Study. / Ahn, Sung Jun; Park, Mi Suk; Kim, Kyung Ah; Park, Jun Yong; Kim, In Seong; Kang, Won Joon; Lee, Seung Koo; Kim, Myeong Jin.

In: PloS one, Vol. 8, No. 8, e71571, 05.08.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 18 F-FDG PET Metabolic Parameters and MRI Perfusion and Diffusion Parameters in Hepatocellular Carcinoma

T2 - A Preliminary Study

AU - Ahn, Sung Jun

AU - Park, Mi Suk

AU - Kim, Kyung Ah

AU - Park, Jun Yong

AU - Kim, In Seong

AU - Kang, Won Joon

AU - Lee, Seung Koo

AU - Kim, Myeong Jin

PY - 2013/8/5

Y1 - 2013/8/5

N2 - Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

AB - Objectives:Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as 18 F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).Materials and Methods:Twenty-one patients with advanced HCC underwent 18 F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV max ) from 18 F-FDG-PET, variables of the volume transfer constant (K trans ) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV max and variables of K trans and ADC was evaluated by Mann-Whitney test.Results:SUV max showed significant negative correlation with K trans max (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K trans or SUV max (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K trans (p>0.05).Conclusion:In this study, SUV was shown to be correlated with K trans in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

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