18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

Hanna Cho; Hee Jin Kim; Jae Yong Choi; Young Hoon Ryu; Myung Sik Lee; Duk L. Na; Sang Won Seo; Chul Hyoung Lyoo

doi:10.1016/j.neurobiolaging.2018.11.017

¹⁸F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

Hanna Cho, Hee Jin Kim, Jae Yong Choi, Young Hoon Ryu, Myung Sik Lee, Duk L. Na, Sang Won Seo, Chul Hyoung Lyoo

Department of Neurology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We analyzed ¹⁸F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using ¹⁸F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. ¹⁸F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. ¹⁸F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased ¹⁸F-flortaucipir uptake. ¹⁸F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.

Original language	English
Pages (from-to)	187-197
Number of pages	11
Journal	Neurobiology of Aging
Volume	75
DOIs	https://doi.org/10.1016/j.neurobiolaging.2018.11.017
Publication status	Published - 2019 Mar

Bibliographical note

Funding Information:
This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for ( 2018-32-0036 ), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507 , 2017R1A2B2006694, and 2017R1A2B2005081 ), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea (grant number: HI18C1159 and HI18C1629 ).

Funding Information:
This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for (2018-32-0036), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507, 2017R1A2B2006694, and 2017R1A2B2005081), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C1159 and HI18C1629).

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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@article{e0ec0d8bd0174404914fec30808517a7,

title = "18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia",

abstract = "We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.",

author = "Hanna Cho and Kim, {Hee Jin} and Choi, {Jae Yong} and Ryu, {Young Hoon} and Lee, {Myung Sik} and Na, {Duk L.} and Seo, {Sang Won} and Lyoo, {Chul Hyoung}",

note = "Funding Information: This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for ( 2018-32-0036 ), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507 , 2017R1A2B2006694, and 2017R1A2B2005081 ), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea (grant number: HI18C1159 and HI18C1629 ). Funding Information: This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for (2018-32-0036), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507, 2017R1A2B2006694, and 2017R1A2B2005081), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C1159 and HI18C1629). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = mar,

doi = "10.1016/j.neurobiolaging.2018.11.017",

language = "English",

volume = "75",

pages = "187--197",

journal = "Neurobiology of Aging",

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T1 - 18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

AU - Cho, Hanna

AU - Kim, Hee Jin

AU - Choi, Jae Yong

AU - Ryu, Young Hoon

AU - Lee, Myung Sik

AU - Na, Duk L.

AU - Seo, Sang Won

AU - Lyoo, Chul Hyoung

N1 - Funding Information: This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for ( 2018-32-0036 ), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507 , 2017R1A2B2006694, and 2017R1A2B2005081 ), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea (grant number: HI18C1159 and HI18C1629 ). Funding Information: This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for (2018-32-0036), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507, 2017R1A2B2006694, and 2017R1A2B2005081), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C1159 and HI18C1629). Publisher Copyright: © 2018 Elsevier Inc.

PY - 2019/3

Y1 - 2019/3

N2 - We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.

AB - We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.

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