18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia

Hanna Cho, Hee Jin Kim, Jae Yong Choi, Young Hoon Ryu, Myung Sik Lee, Duk L. Na, Sang Won Seo, Chul Hyoung Lyoo

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.

Original languageEnglish
Pages (from-to)187-197
Number of pages11
JournalNeurobiology of Aging
Volume75
DOIs
Publication statusPublished - 2019 Mar

Bibliographical note

Funding Information:
This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for ( 2018-32-0036 ), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507 , 2017R1A2B2006694, and 2017R1A2B2005081 ), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare , Republic of Korea (grant number: HI18C1159 and HI18C1629 ).

Funding Information:
This study was financially supported by a faculty research grant of Yonsei University College of Medicine, South Korea for (2018-32-0036), National Research Foundation of Korea, South Korea grant funded by the Korean government (MSIP) (No. 2015R1C1A2A01054507, 2017R1A2B2006694, and 2017R1A2B2005081), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, South Korea (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI18C1159 and HI18C1629).

Publisher Copyright:
© 2018 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of '<sup>18</sup>F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia'. Together they form a unique fingerprint.

Cite this