Abstract
We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.
| Original language | English |
|---|---|
| Pages (from-to) | 187-197 |
| Number of pages | 11 |
| Journal | Neurobiology of Aging |
| Volume | 75 |
| DOIs | |
| Publication status | Published - 2019 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Ageing
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology
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18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. / Cho, Hanna; Kim, Hee Jin; Choi, Jae Yong; Ryu, Young Hoon; Lee, Myung Sik; Na, Duk L.; Seo, Sang Won; Lyoo, Chulhyoung.
In: Neurobiology of Aging, Vol. 75, 01.03.2019, p. 187-197.Research output: Contribution to journal › Article
TY - JOUR
T1 - 18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia
AU - Cho, Hanna
AU - Kim, Hee Jin
AU - Choi, Jae Yong
AU - Ryu, Young Hoon
AU - Lee, Myung Sik
AU - Na, Duk L.
AU - Seo, Sang Won
AU - Lyoo, Chulhyoung
PY - 2019/3/1
Y1 - 2019/3/1
N2 - We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.
AB - We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy controls, and 20 patients with Alzheimer's disease. 18F-flortaucipir uptake was increased in the frontal cortex and underlying white matter, and subcortical nuclei in the 10 nfvPPA and 8 nfvPPA-amyloid-β (Aβ)− subgroup patients. In the svPPA patients (both the 13 svPPA-Aβ− and 5 svPPA-Aβ+), uptake generally increased in the widespread neocortex with left anterior temporal predominance. 18F-flortaucipir uptake patterns in the 6 lvPPA and the 5 lvPPA-Aβ+ subgroup patients were similar to those seen in the patients with Alzheimer's disease with mild predominance in the left lateral temporal cortex. Cortical thinning in each PPA subtype corresponded with increased 18F-flortaucipir uptake. 18F-flortaucipir uptake patterns and cortical atrophy were distinct and corresponded to areas related to the specific language functions that are impaired in each subtype of PPA.
UR - http://www.scopus.com/inward/record.url?scp=85059016018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059016018&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.11.017
DO - 10.1016/j.neurobiolaging.2018.11.017
M3 - Article
VL - 75
SP - 187
EP - 197
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -