[18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

Jee Hae Kang, Minkyung Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Chul Hoon Kim, Kyo Chul Lee, Tae Hyun Choi, Jae Yong Choi

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3 Citations (Scopus)

Abstract

The aim of this study is to compare [18F]FPEB and [18F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [18F]FPEB PET showed higher brain uptake and superior binding potential values than those of [18F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [18F]FPEB and [18F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [18F]FPEB is >4 fold than those of [18F]FDEGPECO. From this evidence, we conclude that [18F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalApplied Radiation and Isotopes
Volume98
DOIs
Publication statusPublished - 2015 Apr 1

Bibliographical note

Funding Information:
This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant no. NRF-2014M2A2A7021043 ).

All Science Journal Classification (ASJC) codes

  • Radiation

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