18F-fluorodeoxyglucose positron emission tomography-computed tomography for the evaluation of bone metastasis in patients with gastric cancer

Dae Won Ma, Jie-Hyun Kim, Tae Joo Jeon, Yongchan Lee, Mijin Yun, Young Hoon Youn, HyoJin Park, Sang In Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The roles of positron emission tomography and bone scanning in identifying bone metastasis in gastric cancer are unclear. Aim: We compared the usefulness of positron emission tomography-computed tomography and scanning in detecting bone metastasis in gastric cancer. Methods: Data from 1485 patients diagnosed with gastric cancer who had undergone positron emission tomography-computed tomography and scanning were reviewed. Of 170 enrolled patients who were suspected of bone metastasis in either positron emission tomography or scanning, 81.2% were confirmed to have bone metastasis. Results: The sensitivity, specificity, and accuracy were 93.5%, 25.0%, and 80.6%, respectively, for positron emission tomography and 93.5%, 37.5%, and 82.9%, respectively, for scanning. 87.7% of patients with bone metastasis showed positive findings on two modalities. 15.0% of solitary bone metastases were positive on positron emission tomography only. Positron emission tomography was superior to scanning for the detection of synchronous bone metastasis, but the two modalities were similar for the detection of metachronous bone metastasis. The concordance rate of response assessment after treatment between two modalities was moderate. Conclusions: Positron emission tomography-computed tomography may be more effective for the diagnosis of bone metastasis in the initial staging workup. Conversely, bone scanning and positron emission tomography-computed tomography may be similarly effective for the detection of metachronous bone metastasis.

Original languageEnglish
Pages (from-to)769-775
Number of pages7
JournalDigestive and Liver Disease
Volume45
Issue number9
DOIs
Publication statusPublished - 2013 Sep 1

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Fluorodeoxyglucose F18
Stomach Neoplasms
Neoplasm Metastasis
Bone and Bones
Positron-Emission Tomography
Positron Emission Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{042c244aa9d444b2aa62b56622b4457b,
title = "18F-fluorodeoxyglucose positron emission tomography-computed tomography for the evaluation of bone metastasis in patients with gastric cancer",
abstract = "Background: The roles of positron emission tomography and bone scanning in identifying bone metastasis in gastric cancer are unclear. Aim: We compared the usefulness of positron emission tomography-computed tomography and scanning in detecting bone metastasis in gastric cancer. Methods: Data from 1485 patients diagnosed with gastric cancer who had undergone positron emission tomography-computed tomography and scanning were reviewed. Of 170 enrolled patients who were suspected of bone metastasis in either positron emission tomography or scanning, 81.2{\%} were confirmed to have bone metastasis. Results: The sensitivity, specificity, and accuracy were 93.5{\%}, 25.0{\%}, and 80.6{\%}, respectively, for positron emission tomography and 93.5{\%}, 37.5{\%}, and 82.9{\%}, respectively, for scanning. 87.7{\%} of patients with bone metastasis showed positive findings on two modalities. 15.0{\%} of solitary bone metastases were positive on positron emission tomography only. Positron emission tomography was superior to scanning for the detection of synchronous bone metastasis, but the two modalities were similar for the detection of metachronous bone metastasis. The concordance rate of response assessment after treatment between two modalities was moderate. Conclusions: Positron emission tomography-computed tomography may be more effective for the diagnosis of bone metastasis in the initial staging workup. Conversely, bone scanning and positron emission tomography-computed tomography may be similarly effective for the detection of metachronous bone metastasis.",
author = "Ma, {Dae Won} and Jie-Hyun Kim and Jeon, {Tae Joo} and Yongchan Lee and Mijin Yun and Youn, {Young Hoon} and HyoJin Park and Lee, {Sang In}",
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18F-fluorodeoxyglucose positron emission tomography-computed tomography for the evaluation of bone metastasis in patients with gastric cancer. / Ma, Dae Won; Kim, Jie-Hyun; Jeon, Tae Joo; Lee, Yongchan; Yun, Mijin; Youn, Young Hoon; Park, HyoJin; Lee, Sang In.

In: Digestive and Liver Disease, Vol. 45, No. 9, 01.09.2013, p. 769-775.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 18F-fluorodeoxyglucose positron emission tomography-computed tomography for the evaluation of bone metastasis in patients with gastric cancer

AU - Ma, Dae Won

AU - Kim, Jie-Hyun

AU - Jeon, Tae Joo

AU - Lee, Yongchan

AU - Yun, Mijin

AU - Youn, Young Hoon

AU - Park, HyoJin

AU - Lee, Sang In

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Background: The roles of positron emission tomography and bone scanning in identifying bone metastasis in gastric cancer are unclear. Aim: We compared the usefulness of positron emission tomography-computed tomography and scanning in detecting bone metastasis in gastric cancer. Methods: Data from 1485 patients diagnosed with gastric cancer who had undergone positron emission tomography-computed tomography and scanning were reviewed. Of 170 enrolled patients who were suspected of bone metastasis in either positron emission tomography or scanning, 81.2% were confirmed to have bone metastasis. Results: The sensitivity, specificity, and accuracy were 93.5%, 25.0%, and 80.6%, respectively, for positron emission tomography and 93.5%, 37.5%, and 82.9%, respectively, for scanning. 87.7% of patients with bone metastasis showed positive findings on two modalities. 15.0% of solitary bone metastases were positive on positron emission tomography only. Positron emission tomography was superior to scanning for the detection of synchronous bone metastasis, but the two modalities were similar for the detection of metachronous bone metastasis. The concordance rate of response assessment after treatment between two modalities was moderate. Conclusions: Positron emission tomography-computed tomography may be more effective for the diagnosis of bone metastasis in the initial staging workup. Conversely, bone scanning and positron emission tomography-computed tomography may be similarly effective for the detection of metachronous bone metastasis.

AB - Background: The roles of positron emission tomography and bone scanning in identifying bone metastasis in gastric cancer are unclear. Aim: We compared the usefulness of positron emission tomography-computed tomography and scanning in detecting bone metastasis in gastric cancer. Methods: Data from 1485 patients diagnosed with gastric cancer who had undergone positron emission tomography-computed tomography and scanning were reviewed. Of 170 enrolled patients who were suspected of bone metastasis in either positron emission tomography or scanning, 81.2% were confirmed to have bone metastasis. Results: The sensitivity, specificity, and accuracy were 93.5%, 25.0%, and 80.6%, respectively, for positron emission tomography and 93.5%, 37.5%, and 82.9%, respectively, for scanning. 87.7% of patients with bone metastasis showed positive findings on two modalities. 15.0% of solitary bone metastases were positive on positron emission tomography only. Positron emission tomography was superior to scanning for the detection of synchronous bone metastasis, but the two modalities were similar for the detection of metachronous bone metastasis. The concordance rate of response assessment after treatment between two modalities was moderate. Conclusions: Positron emission tomography-computed tomography may be more effective for the diagnosis of bone metastasis in the initial staging workup. Conversely, bone scanning and positron emission tomography-computed tomography may be similarly effective for the detection of metachronous bone metastasis.

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JF - Digestive and Liver Disease

SN - 1590-8658

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