[18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis

M. J. Lee, S. L. Kim, H. I. Kim, Y. J. Oh, S. H. Lee, H. K. Kim, C. S. Han, Chulhyoung Lyoo, Y. H. Ryu, M. S. Lee

Research output: Contribution to journalArticle

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Abstract

Backgrounds: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. Methods: We performed [18F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. Results: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. Conclusions: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalParkinsonism and Related Disorders
Volume21
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

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Leukoaraiosis
Denervation
Parkinsonian Disorders
Levodopa
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
Tremor
Basal Ganglia
Positron-Emission Tomography
Blood Vessels
Parkinson Disease
Comorbidity
Leg
Arm
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Lee, M. J., Kim, S. L., Kim, H. I., Oh, Y. J., Lee, S. H., Kim, H. K., ... Lee, M. S. (2015). [18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis. Parkinsonism and Related Disorders, 21(7), 704-708. https://doi.org/10.1016/j.parkreldis.2015.04.007
Lee, M. J. ; Kim, S. L. ; Kim, H. I. ; Oh, Y. J. ; Lee, S. H. ; Kim, H. K. ; Han, C. S. ; Lyoo, Chulhyoung ; Ryu, Y. H. ; Lee, M. S. / [18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis. In: Parkinsonism and Related Disorders. 2015 ; Vol. 21, No. 7. pp. 704-708.
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abstract = "Backgrounds: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. Methods: We performed [18F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. Results: Twenty (48{\%}) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30{\%} improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. Conclusions: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.",
author = "Lee, {M. J.} and Kim, {S. L.} and Kim, {H. I.} and Oh, {Y. J.} and Lee, {S. H.} and Kim, {H. K.} and Han, {C. S.} and Chulhyoung Lyoo and Ryu, {Y. H.} and Lee, {M. S.}",
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Lee, MJ, Kim, SL, Kim, HI, Oh, YJ, Lee, SH, Kim, HK, Han, CS, Lyoo, C, Ryu, YH & Lee, MS 2015, '[18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis', Parkinsonism and Related Disorders, vol. 21, no. 7, pp. 704-708. https://doi.org/10.1016/j.parkreldis.2015.04.007

[18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis. / Lee, M. J.; Kim, S. L.; Kim, H. I.; Oh, Y. J.; Lee, S. H.; Kim, H. K.; Han, C. S.; Lyoo, Chulhyoung; Ryu, Y. H.; Lee, M. S.

In: Parkinsonism and Related Disorders, Vol. 21, No. 7, 01.07.2015, p. 704-708.

Research output: Contribution to journalArticle

TY - JOUR

T1 - [18F] FP-CIT PET study in parkinsonian patients with leukoaraiosis

AU - Lee, M. J.

AU - Kim, S. L.

AU - Kim, H. I.

AU - Oh, Y. J.

AU - Lee, S. H.

AU - Kim, H. K.

AU - Han, C. S.

AU - Lyoo, Chulhyoung

AU - Ryu, Y. H.

AU - Lee, M. S.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Backgrounds: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. Methods: We performed [18F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. Results: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. Conclusions: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.

AB - Backgrounds: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. Methods: We performed [18F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. Results: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. Conclusions: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.

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U2 - 10.1016/j.parkreldis.2015.04.007

DO - 10.1016/j.parkreldis.2015.04.007

M3 - Article

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JF - Parkinsonism and Related Disorders

SN - 1353-8020

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