18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer

Hyuk Hur, Nam Kyu Kim, Mijin Yun, Byung Soh Min, Kang Young Lee, Ki Chang Keum, Jung Bai Ahn, Hoguen Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of surgical oncology
Volume103
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Rectal Neoplasms
Positron-Emission Tomography
Fluorodeoxyglucose F18
Glucose
Neoplasms
Therapeutics
ROC Curve
Area Under Curve
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Hur, Hyuk ; Kim, Nam Kyu ; Yun, Mijin ; Min, Byung Soh ; Lee, Kang Young ; Keum, Ki Chang ; Ahn, Jung Bai ; Kim, Hoguen. / 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. In: Journal of surgical oncology. 2011 ; Vol. 103, No. 1. pp. 17-24.
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title = "18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer",
abstract = "Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9{\%} vs. 58.7{\%}, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6{\%} sensitivity, 79.2{\%} specificity, and 81.2{\%} overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.",
author = "Hyuk Hur and Kim, {Nam Kyu} and Mijin Yun and Min, {Byung Soh} and Lee, {Kang Young} and Keum, {Ki Chang} and Ahn, {Jung Bai} and Hoguen Kim",
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18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. / Hur, Hyuk; Kim, Nam Kyu; Yun, Mijin; Min, Byung Soh; Lee, Kang Young; Keum, Ki Chang; Ahn, Jung Bai; Kim, Hoguen.

In: Journal of surgical oncology, Vol. 103, No. 1, 01.01.2011, p. 17-24.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer

AU - Hur, Hyuk

AU - Kim, Nam Kyu

AU - Yun, Mijin

AU - Min, Byung Soh

AU - Lee, Kang Young

AU - Keum, Ki Chang

AU - Ahn, Jung Bai

AU - Kim, Hoguen

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.

AB - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.

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DO - 10.1002/jso.21736

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SN - 0022-4790

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