Abstract
Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.
| Original language | English |
|---|---|
| Pages (from-to) | 17-24 |
| Number of pages | 8 |
| Journal | Journal of surgical oncology |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
}
18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. / Hur, Hyuk; Kim, Nam Kyu; Yun, Mijin; Min, Byung Soh; Lee, Kang Young; Keum, Ki Chang; Ahn, Jung Bai; Kim, Hoguen.
In: Journal of surgical oncology, Vol. 103, No. 1, 01.01.2011, p. 17-24.Research output: Contribution to journal › Article
TY - JOUR
T1 - 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer
AU - Hur, Hyuk
AU - Kim, Nam Kyu
AU - Yun, Mijin
AU - Min, Byung Soh
AU - Lee, Kang Young
AU - Keum, Ki Chang
AU - Ahn, Jung Bai
AU - Kim, Hoguen
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.
AB - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). Conclusions 18F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.
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U2 - 10.1002/jso.21736
DO - 10.1002/jso.21736
M3 - Article
C2 - 20886551
AN - SCOPUS:78650634420
VL - 103
SP - 17
EP - 24
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 1
ER -