Super-resolution microscopy (SRM) is becoming increasingly important to study nanoscale biological structures. Two most widely used devices for SRM are super-resolution fluorescence microscopy (SRFM) and electron microscopy (EM). For biological living samples, however, SRFM is not preferred since it requires exogenous agents and EM is not preferred since vacuum is required for sample preparation. To overcome these limitations of EM and SFRM, we present a simulation study of super-resolution photoacoustic microscopy (SR-PAM). To break the diffraction limit of light, we investigated a sub-10 nm near-field localization by focusing femtosecond laser pulses under the plasmonic nanoaperture. Using this near-field localization as a light source, we numerically studied the feasibility of the SR-PAM with a k-wave simulation toolbox in MATLAB. In this photoacoustic simulation, we successfully confirmed that the SR-PAM could be a potential method to resolve and image nanoscale structures.
|Journal||IEEE Journal of Selected Topics in Quantum Electronics|
|Publication status||Published - 2019 Mar 1|
Bibliographical noteFunding Information:
Manuscript received September 29, 2017; revised December 8, 2017 and January 13, 2018; accepted January 16, 2018. Date of publication January 24, 2018; date of current version June 8, 2018. This work was supported in part by the ICT Consilience Creative Program under Grant IITP-R0346-16-1007, in part by the National Research Foundation of Korea Engineering Research Center under Grant NRF-2011-0030075, in part by the Korea Health Technology R&D Project of the Ministry of Health and Welfare under Grant HI15C1817, in part by the Tier 1 grant funded by the Ministry of Education in Singapore under Grant RG48/16: M4011617, and in part by the National Research Foundation (NRF) grants funded by the Korean Government under Grant 2015R1A2A1A10052826. Byullee Park and Hongki Lee are both primary authors and contributed equally to this work. (Corresponding authors: Donghyun Kim and Chulhong Kim.) B. Park and C. Kim are with the Creative IT Engineering Department, Pohang University of Science and Technology, Pohang 37673, South Korea (e-mail: firstname.lastname@example.org; email@example.com).
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All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering