Super-resolution Photoacoustic Microscopy Using Near-Field Localization by a Plasmonic Metal Nanoaperture: A Simulation Study

Byullee Park, Hongki Lee, Paul Kumar Upputuri, Manojit Pramanik, Donghyun Kim, Chulhong Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Super-resolution microscopy (SRM) is becoming increasingly important to study nanoscale biological structures. Two most widely used devices for SRM are super-resolution fluorescence microscopy (SRFM) and electron microscopy (EM). For biological living samples, however, SRFM is not preferred since it requires exogenous agents and EM is not preferred since vacuum is required for sample preparation. To overcome these limitations of EM and SFRM, we present a simulation study of super-resolution photoacoustic microscopy (SR-PAM). To break the diffraction limit of light, we investigated a sub-10 nm near-field localization by focusing femtosecond laser pulses under the plasmonic nanoaperture. Using this near-field localization as a light source, we numerically studied the feasibility of the SR-PAM with a k-wave simulation toolbox in MATLAB. In this photoacoustic simulation, we successfully confirmed that the SR-PAM could be a potential method to resolve and image nanoscale structures.

Original languageEnglish
Article number4600107
JournalIEEE Journal of Selected Topics in Quantum Electronics
Volume25
Issue number2
DOIs
Publication statusPublished - 2019 Mar 1

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Photoacoustic microscopy
photoacoustic microscopy
Electron microscopy
near fields
Fluorescence microscopy
Microscopic examination
Metals
metals
Photoacoustic effect
simulation
microscopy
electron microscopy
Ultrashort pulses
MATLAB
Light sources
Diffraction
Vacuum
fluorescence
light sources
vacuum

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Cite this

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abstract = "Super-resolution microscopy (SRM) is becoming increasingly important to study nanoscale biological structures. Two most widely used devices for SRM are super-resolution fluorescence microscopy (SRFM) and electron microscopy (EM). For biological living samples, however, SRFM is not preferred since it requires exogenous agents and EM is not preferred since vacuum is required for sample preparation. To overcome these limitations of EM and SFRM, we present a simulation study of super-resolution photoacoustic microscopy (SR-PAM). To break the diffraction limit of light, we investigated a sub-10 nm near-field localization by focusing femtosecond laser pulses under the plasmonic nanoaperture. Using this near-field localization as a light source, we numerically studied the feasibility of the SR-PAM with a k-wave simulation toolbox in MATLAB. In this photoacoustic simulation, we successfully confirmed that the SR-PAM could be a potential method to resolve and image nanoscale structures.",
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Super-resolution Photoacoustic Microscopy Using Near-Field Localization by a Plasmonic Metal Nanoaperture : A Simulation Study. / Park, Byullee; Lee, Hongki; Upputuri, Paul Kumar; Pramanik, Manojit; Kim, Donghyun; Kim, Chulhong.

In: IEEE Journal of Selected Topics in Quantum Electronics, Vol. 25, No. 2, 4600107, 01.03.2019.

Research output: Contribution to journalArticle

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