Supervised exercise program, BMI, and risk of type 2 diabetes in subjects with normal or impaired fasting glucose

Jey Sook Chae, Ryungwoo Kang, Jung Hyun Kwak, Jean Kyung Paik, Oh Yoen Kim, Minjoo Kim, Ji Won Park, Justin Y. Jeon, Jong Ho Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE - To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk. RESEARCH DESIGN AND METHODS - Korean subjects (n = 7,233; 40-79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice. RESULTS - During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabeteswas positively associatedwith BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. The overweight/obese subjects in the exercise program group exhibited improved fasting glucose compared with the nonexercise program group and showed 1.5 kg of weight loss and a 3-cm decrease in waist circumference. Among overweight/obese subjects with unchanged fasting glucose, weight loss was greater in the exercise program group. CONCLUSIONS - Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.

Original languageEnglish
Pages (from-to)1680-1685
Number of pages6
JournalDiabetes Care
Volume35
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

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Type 2 Diabetes Mellitus
Fasting
Exercise
Glucose
Waist Circumference
Weight Loss
National Health Programs
Research Design
Odds Ratio
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Chae, Jey Sook ; Kang, Ryungwoo ; Kwak, Jung Hyun ; Paik, Jean Kyung ; Kim, Oh Yoen ; Kim, Minjoo ; Park, Ji Won ; Jeon, Justin Y. ; Lee, Jong Ho. / Supervised exercise program, BMI, and risk of type 2 diabetes in subjects with normal or impaired fasting glucose. In: Diabetes Care. 2012 ; Vol. 35, No. 8. pp. 1680-1685.
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abstract = "OBJECTIVE - To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk. RESEARCH DESIGN AND METHODS - Korean subjects (n = 7,233; 40-79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice. RESULTS - During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabeteswas positively associatedwith BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. The overweight/obese subjects in the exercise program group exhibited improved fasting glucose compared with the nonexercise program group and showed 1.5 kg of weight loss and a 3-cm decrease in waist circumference. Among overweight/obese subjects with unchanged fasting glucose, weight loss was greater in the exercise program group. CONCLUSIONS - Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.",
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Supervised exercise program, BMI, and risk of type 2 diabetes in subjects with normal or impaired fasting glucose. / Chae, Jey Sook; Kang, Ryungwoo; Kwak, Jung Hyun; Paik, Jean Kyung; Kim, Oh Yoen; Kim, Minjoo; Park, Ji Won; Jeon, Justin Y.; Lee, Jong Ho.

In: Diabetes Care, Vol. 35, No. 8, 01.08.2012, p. 1680-1685.

Research output: Contribution to journalArticle

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AU - Kang, Ryungwoo

AU - Kwak, Jung Hyun

AU - Paik, Jean Kyung

AU - Kim, Oh Yoen

AU - Kim, Minjoo

AU - Park, Ji Won

AU - Jeon, Justin Y.

AU - Lee, Jong Ho

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N2 - OBJECTIVE - To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk. RESEARCH DESIGN AND METHODS - Korean subjects (n = 7,233; 40-79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice. RESULTS - During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabeteswas positively associatedwith BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. The overweight/obese subjects in the exercise program group exhibited improved fasting glucose compared with the nonexercise program group and showed 1.5 kg of weight loss and a 3-cm decrease in waist circumference. Among overweight/obese subjects with unchanged fasting glucose, weight loss was greater in the exercise program group. CONCLUSIONS - Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.

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