The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).
Bibliographical noteFunding Information:
This work was supported by the Cooperative Research Program for Agriculture Science & Technology Development (project title: Development of functional material for immune enhancement using Weissella cibaria , Rural Development Administration, Republic of Korea [ PJ010835 ]).
© 2018 Elsevier Ltd
All Science Journal Classification (ASJC) codes
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics