Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects

Young Ju Lee, Ayoung Lee, Hye Jin Yoo, Minkyung Kim, Geon Min Noh, Jong Ho Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Functional Foods
Volume48
DOIs
Publication statusPublished - 2018 Sep

Fingerprint

Weissella
Weissella cibaria
natural killer cells
Probiotics
Natural Killer Cells
probiotics
placebos
Placebos
mononuclear leukocytes
Capsules
K562 Cells
immunoglobulins
Immunoglobulins
Blood Cells
cytokines
Stem Cells
T-lymphocytes
cells
Cytokines
assays

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lee, Young Ju ; Lee, Ayoung ; Yoo, Hye Jin ; Kim, Minkyung ; Noh, Geon Min ; Lee, Jong Ho. / Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects. In: Journal of Functional Foods. 2018 ; Vol. 48. pp. 153-158.
@article{324185456dc14da19d84da9aafe12bb7,
title = "Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects",
abstract = "The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).",
author = "Lee, {Young Ju} and Ayoung Lee and Yoo, {Hye Jin} and Minkyung Kim and Noh, {Geon Min} and Lee, {Jong Ho}",
year = "2018",
month = "9",
doi = "10.1016/j.jff.2018.07.009",
language = "English",
volume = "48",
pages = "153--158",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Limited",

}

Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects. / Lee, Young Ju; Lee, Ayoung; Yoo, Hye Jin; Kim, Minkyung; Noh, Geon Min; Lee, Jong Ho.

In: Journal of Functional Foods, Vol. 48, 09.2018, p. 153-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Supplementation with the probiotic strain Weissella cibaria JW15 enhances natural killer cell activity in nondiabetic subjects

AU - Lee, Young Ju

AU - Lee, Ayoung

AU - Yoo, Hye Jin

AU - Kim, Minkyung

AU - Noh, Geon Min

AU - Lee, Jong Ho

PY - 2018/9

Y1 - 2018/9

N2 - The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).

AB - The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 1010 colony forming units (cfu) of W. cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. cibaria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).

UR - http://www.scopus.com/inward/record.url?scp=85049554663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049554663&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2018.07.009

DO - 10.1016/j.jff.2018.07.009

M3 - Article

AN - SCOPUS:85049554663

VL - 48

SP - 153

EP - 158

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -