Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects

Saem Jung; Young Ju Lee; Minkyung Kim; Minjoo Kim; Jung Hyun Kwak; Ji Won Lee; Young Tae Ahn; Jae Hun Sim; Jong Ho Lee

doi:10.1016/j.jff.2015.10.006

Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA₂ activity in overweight subjects

Saem Jung, Young Ju Lee, Minkyung Kim, Minjoo Kim, Jung Hyun Kwak, Ji Won Lee, Young Tae Ahn, Jae Hun Sim, Jong Ho Lee

Department of Food and Nutrition

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm²) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA₂ (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA₂ (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA₂ activities (ClinicalTrials.gov: NCT02492698).

Original language	English
Article number	1300
Pages (from-to)	744-752
Number of pages	9
Journal	Journal of Functional Foods
Volume	19
DOIs	https://doi.org/10.1016/j.jff.2015.10.006
Publication status	Published - 2015 Dec

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program ( NRF-2012M3A9C4048762 ) of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning, Korea, and “Food Functionality Evaluation program” under the Ministry of Food, Agriculture, Forestry and Fisheries, Korea.

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1016/j.jff.2015.10.006

Cite this

Jung, S., Lee, Y. J., Kim, M., Kim, M., Kwak, J. H., Lee, J. W., Ahn, Y. T., Sim, J. H., & Lee, J. H. (2015). Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA₂ activity in overweight subjects. Journal of Functional Foods, 19, 744-752. [1300]. https://doi.org/10.1016/j.jff.2015.10.006

Jung, Saem ; Lee, Young Ju ; Kim, Minkyung ; Kim, Minjoo ; Kwak, Jung Hyun ; Lee, Ji Won ; Ahn, Young Tae ; Sim, Jae Hun ; Lee, Jong Ho. / Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA₂ activity in overweight subjects. In: Journal of Functional Foods. 2015 ; Vol. 19. pp. 744-752.

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title = "Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects",

abstract = "The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).",

author = "Saem Jung and Lee, {Young Ju} and Minkyung Kim and Minjoo Kim and Kwak, {Jung Hyun} and Lee, {Ji Won} and Ahn, {Young Tae} and Sim, {Jae Hun} and Lee, {Jong Ho}",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program ( NRF-2012M3A9C4048762 ) of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning, Korea, and “Food Functionality Evaluation program” under the Ministry of Food, Agriculture, Forestry and Fisheries, Korea. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

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doi = "10.1016/j.jff.2015.10.006",

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volume = "19",

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Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA₂ activity in overweight subjects. / Jung, Saem; Lee, Young Ju; Kim, Minkyung; Kim, Minjoo; Kwak, Jung Hyun; Lee, Ji Won; Ahn, Young Tae; Sim, Jae Hun; Lee, Jong Ho.

In: Journal of Functional Foods, Vol. 19, 1300, 12.2015, p. 744-752.

Research output: Contribution to journal › Article › peer-review

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AU - Jung, Saem

AU - Lee, Young Ju

AU - Kim, Minkyung

AU - Kim, Minjoo

AU - Kwak, Jung Hyun

AU - Lee, Ji Won

AU - Ahn, Young Tae

AU - Sim, Jae Hun

AU - Lee, Jong Ho

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program ( NRF-2012M3A9C4048762 ) of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning, Korea, and “Food Functionality Evaluation program” under the Ministry of Food, Agriculture, Forestry and Fisheries, Korea. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/12

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N2 - The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).

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