Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA₂ activity in overweight subjects

The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm²) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA₂ (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA₂ (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA₂ activities (ClinicalTrials.gov: NCT02492698).