Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects

Saem Jung, Young Ju Lee, Minkyung Kim, Minjoo Kim, Jung Hyun Kwak, Ji Won Lee, Young Tae Ahn, Jae Hun Sim, Jong Ho Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).

Original languageEnglish
Article number1300
Pages (from-to)744-752
Number of pages9
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - 2015 Dec 1

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1-Alkyl-2-acetylglycerophosphocholine Esterase
Lactobacillus curvatus
Lactobacillus plantarum
phospholipase A2
Adiposity
Probiotics
adiposity
Lactobacillus
lipoproteins
probiotics
low density lipoprotein
body fat
Adipose Tissue
Weight Loss
weight loss
Fats
Subcutaneous Fat
subcutaneous fat
lipids
LDL Lipoproteins

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Jung, Saem ; Lee, Young Ju ; Kim, Minkyung ; Kim, Minjoo ; Kwak, Jung Hyun ; Lee, Ji Won ; Ahn, Young Tae ; Sim, Jae Hun ; Lee, Jong Ho. / Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects. In: Journal of Functional Foods. 2015 ; Vol. 19. pp. 744-752.
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abstract = "The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19{\%}) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).",
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Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects. / Jung, Saem; Lee, Young Ju; Kim, Minkyung; Kim, Minjoo; Kwak, Jung Hyun; Lee, Ji Won; Ahn, Young Tae; Sim, Jae Hun; Lee, Jong Ho.

In: Journal of Functional Foods, Vol. 19, 1300, 01.12.2015, p. 744-752.

Research output: Contribution to journalArticle

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