The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).
Bibliographical noteFunding Information:
This research was supported by the Bio & Medical Technology Development Program ( NRF-2012M3A9C4048762 ) of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT & Future Planning, Korea, and “Food Functionality Evaluation program” under the Ministry of Food, Agriculture, Forestry and Fisheries, Korea.
© 2015 Elsevier Ltd.
All Science Journal Classification (ASJC) codes
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics