Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects

Saem Jung, Young Ju Lee, Minkyung Kim, Minjoo Kim, Jung Hyun Kwak, Ji Won Lee, Young Tae Ahn, Jae Hun Sim, Jong Ho Lee

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22 Citations (Scopus)

Abstract

The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (-0.65 ± 0.23 kg), body fat percentage (-0.57 ± 0.19%) and body fat mass (-616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (-2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (▵, difference from baseline) in total fat mass correlated with ▵ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with ▵ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).

Original languageEnglish
Article number1300
Pages (from-to)744-752
Number of pages9
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - 2015 Dec

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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