Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster

KiTaek Nam, Dae Yong Kim, Mi Sun Park, Dong Deuk Jang, Ki Hwa Yang, Jeong Hee Han, Byung Il Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalJournal of Toxicologic Pathology
Volume18
Issue number1
DOIs
Publication statusPublished - 2005 Nov 8

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Fasciola hepatica
Cholangiocarcinoma
Cricetinae
Liver
Tumors
Clonorchis sinensis
Neoplasms
Metacercariae
Dimethylnitrosamine
Drinking Water
pimagedine
Infection

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology

Cite this

Nam, KiTaek ; Kim, Dae Yong ; Park, Mi Sun ; Jang, Dong Deuk ; Yang, Ki Hwa ; Han, Jeong Hee ; Yoon, Byung Il. / Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster. In: Journal of Toxicologic Pathology. 2005 ; Vol. 18, No. 1. pp. 65-68.
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abstract = "Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1{\%} aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005",
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Suppression of cholangiocarcinoma development by aminoguanidine in the liver fluke-infested hamster. / Nam, KiTaek; Kim, Dae Yong; Park, Mi Sun; Jang, Dong Deuk; Yang, Ki Hwa; Han, Jeong Hee; Yoon, Byung Il.

In: Journal of Toxicologic Pathology, Vol. 18, No. 1, 08.11.2005, p. 65-68.

Research output: Contribution to journalArticle

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AB - Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted. 2005

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