Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

Juhyun Song, Yumi Oh, Jong Youl Kim, Kyoung Joo Cho, Jong Eun Lee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

Original languageEnglish
Pages (from-to)1461-1467
Number of pages7
JournalYonsei medical journal
Issue number6
Publication statusPublished - 2016 Nov

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2014R1A2A2A01006556).

Publisher Copyright:
© Yonsei University College of Medicine 2016.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation'. Together they form a unique fingerprint.

Cite this