Abstract
Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 1461-1467 |
| Number of pages | 7 |
| Journal | Yonsei medical journal |
| Volume | 57 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 Nov |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
}
Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation. / Song, Juhyun; Oh, Yumi; Kim, Jong Youl; Cho, Kyoung Joo; Lee, Jong Eun.
In: Yonsei medical journal, Vol. 57, No. 6, 11.2016, p. 1461-1467.Research output: Contribution to journal › Article
TY - JOUR
T1 - Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation
AU - Song, Juhyun
AU - Oh, Yumi
AU - Kim, Jong Youl
AU - Cho, Kyoung Joo
AU - Lee, Jong Eun
PY - 2016/11
Y1 - 2016/11
N2 - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
AB - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
UR - http://www.scopus.com/inward/record.url?scp=84986904939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84986904939&partnerID=8YFLogxK
U2 - 10.3349/ymj.2016.57.6.1461
DO - 10.3349/ymj.2016.57.6.1461
M3 - Article
C2 - 27593875
AN - SCOPUS:84986904939
VL - 57
SP - 1461
EP - 1467
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
SN - 0513-5796
IS - 6
ER -