Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

Juhyun Song, Yumi Oh, Jong Youl Kim, Kyoung Joo Cho, Jong Eun Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

Original languageEnglish
Pages (from-to)1461-1467
Number of pages7
JournalYonsei medical journal
Volume57
Issue number6
DOIs
Publication statusPublished - 2016 Nov

Fingerprint

Agmatine
Neural Stem Cells
MicroRNAs
Cell Differentiation
Central Nervous System Diseases
Central Nervous System
Biogenic Amines
Neurogenesis
Cell Proliferation
Neurons
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Song, Juhyun ; Oh, Yumi ; Kim, Jong Youl ; Cho, Kyoung Joo ; Lee, Jong Eun. / Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation. In: Yonsei medical journal. 2016 ; Vol. 57, No. 6. pp. 1461-1467.
@article{26a22c74d94b4d7f9522c7ea125a0b43,
title = "Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation",
abstract = "Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.",
author = "Juhyun Song and Yumi Oh and Kim, {Jong Youl} and Cho, {Kyoung Joo} and Lee, {Jong Eun}",
year = "2016",
month = "11",
doi = "10.3349/ymj.2016.57.6.1461",
language = "English",
volume = "57",
pages = "1461--1467",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "6",

}

Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation. / Song, Juhyun; Oh, Yumi; Kim, Jong Youl; Cho, Kyoung Joo; Lee, Jong Eun.

In: Yonsei medical journal, Vol. 57, No. 6, 11.2016, p. 1461-1467.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

AU - Song, Juhyun

AU - Oh, Yumi

AU - Kim, Jong Youl

AU - Cho, Kyoung Joo

AU - Lee, Jong Eun

PY - 2016/11

Y1 - 2016/11

N2 - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

AB - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

UR - http://www.scopus.com/inward/record.url?scp=84986904939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84986904939&partnerID=8YFLogxK

U2 - 10.3349/ymj.2016.57.6.1461

DO - 10.3349/ymj.2016.57.6.1461

M3 - Article

C2 - 27593875

AN - SCOPUS:84986904939

VL - 57

SP - 1461

EP - 1467

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 6

ER -