Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

Juhyun Song; Yumi Oh; Jong Youl Kim; Kyoung Joo Cho; Jong Eun Lee

doi:10.3349/ymj.2016.57.6.1461

Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

Juhyun Song, Yumi Oh, Jong Youl Kim, Kyoung Joo Cho, Jong Eun Lee

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

Original language	English
Pages (from-to)	1461-1467
Number of pages	7
Journal	Yonsei medical journal
Volume	57
Issue number	6
DOIs	https://doi.org/10.3349/ymj.2016.57.6.1461
Publication status	Published - 2016 Nov

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2014R1A2A2A01006556).

Publisher Copyright:
© Yonsei University College of Medicine 2016.

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Medicine(all)

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title = "Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation",

abstract = "Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.",

author = "Juhyun Song and Yumi Oh and Kim, {Jong Youl} and Cho, {Kyoung Joo} and Lee, {Jong Eun}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2014R1A2A2A01006556). Publisher Copyright: {\textcopyright} Yonsei University College of Medicine 2016.",

year = "2016",

month = nov,

doi = "10.3349/ymj.2016.57.6.1461",

language = "English",

volume = "57",

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AU - Song, Juhyun

AU - Oh, Yumi

AU - Kim, Jong Youl

AU - Cho, Kyoung Joo

AU - Lee, Jong Eun

N1 - Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2014R1A2A2A01006556). Publisher Copyright: © Yonsei University College of Medicine 2016.

PY - 2016/11

Y1 - 2016/11

N2 - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

AB - Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis. Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression. Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a. Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

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Suppression of microRNA let-7a expression by agmatine regulates neural stem cell differentiation

Abstract

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