Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices

Woo Dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recently, dendrimers are attracting much attention for their development as biomedical nano-devices. In the present paper, we introduce dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, for photodynamic therapy (PDT). Ionic dendritic porphyrins (DPs) formed supramolecular polyion complex (PIC) micelles through the electrostatic interaction with oppositely charged block copolymers, and showed no self-quenching effect of the focal photosensitizing unit due to the large dendritic wedges. The DP-loaded PIC micelles showed selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect. For the effective light delivery, dendrimer phthalocyanine (DPc) has also been developed and examined for its photodynamic effect.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalSupramolecular Chemistry
Volume19
Issue number4-5
DOIs
Publication statusPublished - 2007 Jun 1

Fingerprint

Dendrimers
Porphyrins
Micelles
Photodynamic therapy
Photosensitizing Agents
Coulomb interactions
Ether
Block copolymers
Quenching

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Jang, Woo Dong ; Nishiyama, Nobuhiro ; Kataoka, Kazunori. / Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices. In: Supramolecular Chemistry. 2007 ; Vol. 19, No. 4-5. pp. 309-314.
@article{823de6b1df7d4700ae090d4fdd0c1105,
title = "Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices",
abstract = "Recently, dendrimers are attracting much attention for their development as biomedical nano-devices. In the present paper, we introduce dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, for photodynamic therapy (PDT). Ionic dendritic porphyrins (DPs) formed supramolecular polyion complex (PIC) micelles through the electrostatic interaction with oppositely charged block copolymers, and showed no self-quenching effect of the focal photosensitizing unit due to the large dendritic wedges. The DP-loaded PIC micelles showed selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect. For the effective light delivery, dendrimer phthalocyanine (DPc) has also been developed and examined for its photodynamic effect.",
author = "Jang, {Woo Dong} and Nobuhiro Nishiyama and Kazunori Kataoka",
year = "2007",
month = "6",
day = "1",
doi = "10.1080/10610270701324089",
language = "English",
volume = "19",
pages = "309--314",
journal = "Supramolecular Chemistry",
issn = "1061-0278",
publisher = "Taylor and Francis Ltd.",
number = "4-5",

}

Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices. / Jang, Woo Dong; Nishiyama, Nobuhiro; Kataoka, Kazunori.

In: Supramolecular Chemistry, Vol. 19, No. 4-5, 01.06.2007, p. 309-314.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Kataoka, Kazunori

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Recently, dendrimers are attracting much attention for their development as biomedical nano-devices. In the present paper, we introduce dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, for photodynamic therapy (PDT). Ionic dendritic porphyrins (DPs) formed supramolecular polyion complex (PIC) micelles through the electrostatic interaction with oppositely charged block copolymers, and showed no self-quenching effect of the focal photosensitizing unit due to the large dendritic wedges. The DP-loaded PIC micelles showed selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect. For the effective light delivery, dendrimer phthalocyanine (DPc) has also been developed and examined for its photodynamic effect.

AB - Recently, dendrimers are attracting much attention for their development as biomedical nano-devices. In the present paper, we introduce dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, for photodynamic therapy (PDT). Ionic dendritic porphyrins (DPs) formed supramolecular polyion complex (PIC) micelles through the electrostatic interaction with oppositely charged block copolymers, and showed no self-quenching effect of the focal photosensitizing unit due to the large dendritic wedges. The DP-loaded PIC micelles showed selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect. For the effective light delivery, dendrimer phthalocyanine (DPc) has also been developed and examined for its photodynamic effect.

UR - http://www.scopus.com/inward/record.url?scp=34547945784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547945784&partnerID=8YFLogxK

U2 - 10.1080/10610270701324089

DO - 10.1080/10610270701324089

M3 - Article

AN - SCOPUS:34547945784

VL - 19

SP - 309

EP - 314

JO - Supramolecular Chemistry

JF - Supramolecular Chemistry

SN - 1061-0278

IS - 4-5

ER -