Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Dong Lin Jiang, Satoko Kawauchi, Yuji Morimoto, Makoto Kikuchi, Hiroyuki Koyama, Takuzo Aida, Kazunori Kataoka

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)

Abstract

Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number3
DOIs
Publication statusPublished - 2005 Jan 3

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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