Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy

Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Dong Lin Jiang, Satoko Kawauchi, Yuji Morimoto, Makoto Kikuchi, Hiroyuki Koyama, Takuzo Aida, Kazunori Kataoka

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly(ethylene glycol)poly(L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy. (Figure Presented).

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number3
DOIs
Publication statusPublished - 2005 Jan 3

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Dendrimers
Porphyrins
Micelles
Polyethylene glycols
Block copolymers
Lysine
Tumors
Electrostatics
Hydrodynamics

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Jang, Woo Dong ; Nishiyama, Nobuhiro ; Zhang, Guo Dong ; Harada, Atsushi ; Jiang, Dong Lin ; Kawauchi, Satoko ; Morimoto, Yuji ; Kikuchi, Makoto ; Koyama, Hiroyuki ; Aida, Takuzo ; Kataoka, Kazunori. / Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 3. pp. 419-423.
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Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. / Jang, Woo Dong; Nishiyama, Nobuhiro; Zhang, Guo Dong; Harada, Atsushi; Jiang, Dong Lin; Kawauchi, Satoko; Morimoto, Yuji; Kikuchi, Makoto; Koyama, Hiroyuki; Aida, Takuzo; Kataoka, Kazunori.

In: Angewandte Chemie - International Edition, Vol. 44, No. 3, 03.01.2005, p. 419-423.

Research output: Contribution to journalArticle

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AU - Harada, Atsushi

AU - Jiang, Dong Lin

AU - Kawauchi, Satoko

AU - Morimoto, Yuji

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AU - Aida, Takuzo

AU - Kataoka, Kazunori

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