Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing

Keiji Itaka, Naoki Kanayama, Nobuhiro Nishiyama, Woo Dong Jang, Yuichi Yamasaki, Kozo Nakamura, Hiroshi Kawaguchi, Kazunori Kataoka

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pKa values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.

Original languageEnglish
Pages (from-to)13612-13613
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number42
DOIs
Publication statusPublished - 2004 Oct 27

Fingerprint

Diamines
Gene Silencing
Complexation
Self assembly
Small Interfering RNA
Polyethylene glycols
Genes
Gene Knockdown Techniques
Endosomes
Serum

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Itaka, Keiji ; Kanayama, Naoki ; Nishiyama, Nobuhiro ; Jang, Woo Dong ; Yamasaki, Yuichi ; Nakamura, Kozo ; Kawaguchi, Hiroshi ; Kataoka, Kazunori. / Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 42. pp. 13612-13613.
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Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. / Itaka, Keiji; Kanayama, Naoki; Nishiyama, Nobuhiro; Jang, Woo Dong; Yamasaki, Yuichi; Nakamura, Kozo; Kawaguchi, Hiroshi; Kataoka, Kazunori.

In: Journal of the American Chemical Society, Vol. 126, No. 42, 27.10.2004, p. 13612-13613.

Research output: Contribution to journalArticle

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AU - Jang, Woo Dong

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AU - Nakamura, Kozo

AU - Kawaguchi, Hiroshi

AU - Kataoka, Kazunori

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