Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing

Keiji Itaka; Naoki Kanayama; Nobuhiro Nishiyama; Woo Dong Jang; Yuichi Yamasaki; Kozo Nakamura; Hiroshi Kawaguchi; Kazunori Kataoka

doi:10.1021/ja047174r

Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK_a directed to enhance intracellular gene silencing

Keiji Itaka, Naoki Kanayama, Nobuhiro Nishiyama, Woo Dong Jang, Yuichi Yamasaki, Kozo Nakamura, Hiroshi Kawaguchi, Kazunori Kataoka

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pK_a values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.

Original language	English
Pages (from-to)	13612-13613
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	42
DOIs	https://doi.org/10.1021/ja047174r
Publication status	Published - 2004 Oct 27

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja047174r

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Itaka, K., Kanayama, N., Nishiyama, N., Jang, W. D., Yamasaki, Y., Nakamura, K., Kawaguchi, H., & Kataoka, K. (2004). Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK_a directed to enhance intracellular gene silencing. Journal of the American Chemical Society, 126(42), 13612-13613. https://doi.org/10.1021/ja047174r

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abstract = "An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pKa values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.",

author = "Keiji Itaka and Naoki Kanayama and Nobuhiro Nishiyama and Jang, {Woo Dong} and Yuichi Yamasaki and Kozo Nakamura and Hiroshi Kawaguchi and Kazunori Kataoka",

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Itaka, K, Kanayama, N, Nishiyama, N, Jang, WD, Yamasaki, Y, Nakamura, K, Kawaguchi, H & Kataoka, K 2004, 'Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK_a directed to enhance intracellular gene silencing', Journal of the American Chemical Society, vol. 126, no. 42, pp. 13612-13613. https://doi.org/10.1021/ja047174r

Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK_a directed to enhance intracellular gene silencing. / Itaka, Keiji; Kanayama, Naoki; Nishiyama, Nobuhiro et al.

In: Journal of the American Chemical Society, Vol. 126, No. 42, 27.10.2004, p. 13612-13613.

Research output: Contribution to journal › Article › peer-review

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AU - Itaka, Keiji

AU - Kanayama, Naoki

AU - Nishiyama, Nobuhiro

AU - Jang, Woo Dong

AU - Yamasaki, Yuichi

AU - Nakamura, Kozo

AU - Kawaguchi, Hiroshi

AU - Kataoka, Kazunori

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Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pK_a directed to enhance intracellular gene silencing

Abstract

All Science Journal Classification (ASJC) codes

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