An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pKa values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2004 Oct 27|
All Science Journal Classification (ASJC) codes
- Colloid and Surface Chemistry