Surface Chemistry of Vitamin: Pyridoxal 5′-Phosphate (Vitamin B6) as a Multifunctional Compound for Surface Functionalization

Jung Seung Lee, Kyuri Kim, Kihong Lee, Joseph P. Park, Kisuk Yang, Seung-Woo Cho, Haeshin Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Vitamins are non-toxic compounds that perform a variety of biological functions and also available in a large quantity. Other than the usage as food supplements, few attempts have been made to use them as functional materials. In this study, we report that vitamin B6, pyridoxal 5′-phosphate (PLP), is a multi-functional molecule for oxide surface chemistry. PLP-immobilized surfaces exhibit superhydrophilicity and even hemophilicity, enhancing proliferation, migration, and differentiation of mammalian cells. Unlike existing molecules used so far in surface modification, PLP has an intrinsic chemical reactivity toward biomacromolecules due to the presence of the aldehyde group. In fact, RGD peptide is covalently tethered onto PLP surfaces directly in one step without any chemical activation. Furthermore, PLP-functionalized implant device showed rapid bone healing. As vitamin B6 is a FDA approved molecule for human usage, the surface chemistry of vitamin B6 potentially allows a fast route for surface functionalized medical devices into clinic.

Original languageEnglish
Pages (from-to)4754-4760
Number of pages7
JournalAdvanced Functional Materials
Volume25
Issue number30
DOIs
Publication statusPublished - 2015 Aug 1

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vitamins
Vitamin B 6
Pyridoxal Phosphate
Vitamins
Surface chemistry
phosphates
Phosphates
chemistry
Molecules
Chemical reactivity
Functional materials
molecules
Aldehydes
Oxides
Peptides
healing
supplements
Surface treatment
aldehydes
Bone

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Lee, Jung Seung ; Kim, Kyuri ; Lee, Kihong ; Park, Joseph P. ; Yang, Kisuk ; Cho, Seung-Woo ; Lee, Haeshin. / Surface Chemistry of Vitamin : Pyridoxal 5′-Phosphate (Vitamin B6) as a Multifunctional Compound for Surface Functionalization. In: Advanced Functional Materials. 2015 ; Vol. 25, No. 30. pp. 4754-4760.
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Surface Chemistry of Vitamin : Pyridoxal 5′-Phosphate (Vitamin B6) as a Multifunctional Compound for Surface Functionalization. / Lee, Jung Seung; Kim, Kyuri; Lee, Kihong; Park, Joseph P.; Yang, Kisuk; Cho, Seung-Woo; Lee, Haeshin.

In: Advanced Functional Materials, Vol. 25, No. 30, 01.08.2015, p. 4754-4760.

Research output: Contribution to journalArticle

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