TY - JOUR
T1 - Surface Chemistry of Vitamin
T2 - Pyridoxal 5′-Phosphate (Vitamin B6) as a Multifunctional Compound for Surface Functionalization
AU - Lee, Jung Seung
AU - Kim, Kyuri
AU - Lee, Kihong
AU - Park, Joseph P.
AU - Yang, Kisuk
AU - Cho, Seung Woo
AU - Lee, Haeshin
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Vitamins are non-toxic compounds that perform a variety of biological functions and also available in a large quantity. Other than the usage as food supplements, few attempts have been made to use them as functional materials. In this study, we report that vitamin B6, pyridoxal 5′-phosphate (PLP), is a multi-functional molecule for oxide surface chemistry. PLP-immobilized surfaces exhibit superhydrophilicity and even hemophilicity, enhancing proliferation, migration, and differentiation of mammalian cells. Unlike existing molecules used so far in surface modification, PLP has an intrinsic chemical reactivity toward biomacromolecules due to the presence of the aldehyde group. In fact, RGD peptide is covalently tethered onto PLP surfaces directly in one step without any chemical activation. Furthermore, PLP-functionalized implant device showed rapid bone healing. As vitamin B6 is a FDA approved molecule for human usage, the surface chemistry of vitamin B6 potentially allows a fast route for surface functionalized medical devices into clinic.
AB - Vitamins are non-toxic compounds that perform a variety of biological functions and also available in a large quantity. Other than the usage as food supplements, few attempts have been made to use them as functional materials. In this study, we report that vitamin B6, pyridoxal 5′-phosphate (PLP), is a multi-functional molecule for oxide surface chemistry. PLP-immobilized surfaces exhibit superhydrophilicity and even hemophilicity, enhancing proliferation, migration, and differentiation of mammalian cells. Unlike existing molecules used so far in surface modification, PLP has an intrinsic chemical reactivity toward biomacromolecules due to the presence of the aldehyde group. In fact, RGD peptide is covalently tethered onto PLP surfaces directly in one step without any chemical activation. Furthermore, PLP-functionalized implant device showed rapid bone healing. As vitamin B6 is a FDA approved molecule for human usage, the surface chemistry of vitamin B6 potentially allows a fast route for surface functionalized medical devices into clinic.
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U2 - 10.1002/adfm.201501471
DO - 10.1002/adfm.201501471
M3 - Article
VL - 25
SP - 4754
EP - 4760
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 30
ER -