Surface functionalization of SBA-15 particles for ibuprofen delivery

Dae Hyun Hwang, Deokkyu Lee, Hosub Lee, Dongcheol Choe, Sang Hoon Lee, Kangtaek Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have synthesized SBA-15 particles and functionalized their surface with different functional groups (amine, diamine, and sulfonic acid groups) to use them as carrier materials in drug delivery. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen sorption, and zeta potential measurements were used to characterize the synthesized particles. After surface functionalization, the surface of the sulfonic acid-functionalized particles was more acidic than that of the other particles. Using ibuprofen as a model drug, we found that the release rate increased at higher pH. Furthermore, the particles with the sulfonic acid groups exhibited higher release rate than those with the amine and diamine groups. We explained the difference in the release rate using different electrostatic interaction between drug and particle surface that was caused by the surface functionalization. These results should enable design of drug carrier materials based on the SBA-15 particles with the desired release rate.

Original languageEnglish
Pages (from-to)1087-1092
Number of pages6
JournalKorean Journal of Chemical Engineering
Volume27
Issue number4
DOIs
Publication statusPublished - 2010 Jun 8

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Ibuprofen
Sulfonic Acids
Diamines
Amines
Acids
Drug Carriers
Zeta potential
Coulomb interactions
Drug delivery
Pharmaceutical Preparations
Functional groups
Sorption
Nitrogen
SBA-15
Transmission electron microscopy
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Hwang, Dae Hyun ; Lee, Deokkyu ; Lee, Hosub ; Choe, Dongcheol ; Lee, Sang Hoon ; Lee, Kangtaek. / Surface functionalization of SBA-15 particles for ibuprofen delivery. In: Korean Journal of Chemical Engineering. 2010 ; Vol. 27, No. 4. pp. 1087-1092.
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Surface functionalization of SBA-15 particles for ibuprofen delivery. / Hwang, Dae Hyun; Lee, Deokkyu; Lee, Hosub; Choe, Dongcheol; Lee, Sang Hoon; Lee, Kangtaek.

In: Korean Journal of Chemical Engineering, Vol. 27, No. 4, 08.06.2010, p. 1087-1092.

Research output: Contribution to journalArticle

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AU - Choe, Dongcheol

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AU - Lee, Kangtaek

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