Surface-functionalized nanoparticles for controlled drug delivery.

Sung Wook Choi, Woo Sik Kim, Jung-Hyun Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

Original languageEnglish
Pages (from-to)121-131
Number of pages11
JournalMethods in molecular biology (Clifton, N.J.)
Volume303
Publication statusPublished - 2005 Jan 1

Fingerprint

Nanoparticles
Tetracycline
Pharmaceutical Preparations
glycolic acid
Carbodiimides
Bone and Bones
Drug Delivery Systems
Dialysis

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

@article{9d0f90504bc04af1bf2c3e39f5569d6a,
title = "Surface-functionalized nanoparticles for controlled drug delivery.",
abstract = "Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.",
author = "Choi, {Sung Wook} and Kim, {Woo Sik} and Jung-Hyun Kim",
year = "2005",
month = "1",
day = "1",
language = "English",
volume = "303",
pages = "121--131",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

Surface-functionalized nanoparticles for controlled drug delivery. / Choi, Sung Wook; Kim, Woo Sik; Kim, Jung-Hyun.

In: Methods in molecular biology (Clifton, N.J.), Vol. 303, 01.01.2005, p. 121-131.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Surface-functionalized nanoparticles for controlled drug delivery.

AU - Choi, Sung Wook

AU - Kim, Woo Sik

AU - Kim, Jung-Hyun

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

AB - Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

UR - http://www.scopus.com/inward/record.url?scp=22844448293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844448293&partnerID=8YFLogxK

M3 - Article

C2 - 15923680

AN - SCOPUS:22844448293

VL - 303

SP - 121

EP - 131

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -