Surface-functionalized nanoparticles for controlled drug delivery.

Sung Wook Choi, Woo Sik Kim, Jung-Hyun Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nanoparticles have been extensively investigated in drug-delivery systems. Especially, the effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules, is well demonstrated. This chapter describes the complete technique for the preparation of surface-functionalized nanoparticles. Tetracycline with an affinity to bone was chosen as a model material for surface functionalization. There are two steps for the preparation of tetracycline-modified nanoparticles. The first step is the conjugation of poly(D,L-lactide-co- glycolic acid) with tetracycline via carbodiimide chemistry and is the most often employed. Three kinds of techniques--the emulsification-diffusion method, nanoprecipitation, and the dialysis method are used for nanoparticle formation of the resulting copolymer. Prepared nanoparticles having a size <200 nm and a hydrophilic surface layer can be applied for bone-specific drug delivery.

Original languageEnglish
Pages (from-to)121-131
Number of pages11
JournalMethods in molecular biology (Clifton, N.J.)
Volume303
Publication statusPublished - 2005 Jan 1

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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