Surface modification for enhancing behaviors of vascular endothelial cells onto polyurethane films by microwave-induced argon plasma

Hye Ryeon Lim, Hyun Sook Baek, Mi Hee Lee, Yeon I. Woo, Dong Wook Han, Man Hyeop Han, Hong Koo Baik, Won Sup Choi, Ki Dong Park, Kie Hyung Chung, Jong Chul Park

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Polyurethanes (PUs) are widely used in cardiovascular and other biomedical applications due to their good biocompatibility as well as mechanical properties. However, PUs are poor substrates in supporting the adhesion and growth of vascular endothelial cells. In this study, the surface of PU films was modified by microwave-induced argon plasma treatment in order to improve the hemocompatibility of the films used as cardiovascular prostheses including vascular grafts and stents. The modified surface of PU films was characterized by water contact angle measurement, atomic force microscopy and scanning electron microscopy. Plasma treatment resulted in an appreciable increase in the surface roughness of PU films with a concomitant decrease in the contact angle of the films, suggesting that the hydrophilicity of the film surface might be subsequently enhanced. Furthermore, the cellular behaviors of human umbilical vascular endothelial cells, such as attachment, growth and proliferation, were significantly increased onto the surface-modified PU films. In conclusion, the surface modification of PU films by microwave-induced plasma could enhance the behaviors of endothelial cells and the method would be usefully applied to cardiovascular tissue engineering.

Original languageEnglish
Pages (from-to)5768-5772
Number of pages5
JournalSurface and Coatings Technology
Volume202
Issue number22-23
DOIs
Publication statusPublished - 2008 Aug 30

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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