Surface modification of functional nanoparticles for controlled drug delivery

Sung Wook Choi, Woo Sik Kim, Jung Hyun Kim

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Surface-modified nanoparticles have received much attention as drug carriers. Natural and synthetic polymers are used as the materials to prepare nanoparticles and the properties of these nanoparticles originate with these polymeric materials. In particular, these nanoparticles are modified for specific objectives. The surface characteristics of (shell) nanoparticles are more important than those of the core, because the shell layer directly contacts body fluids and organs. Generally, the nanoparticles are coated with hydrophilic polymer to give long circulation and/or are conjugated with functional ligands or proteins for site-specific delivery. In this review, the preparative methods and the applications of surface modification of polymeric functionalized nanoparticles for long-circulation, site-specific delivery, and oral delivery are discussed.

Original languageEnglish
Pages (from-to)475-487
Number of pages13
JournalJournal of Dispersion Science and Technology
Volume24
Issue number3-4
DOIs
Publication statusPublished - 2003 May 1

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Polymers and Plastics

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